WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562203
CAS#: 166038-00-2
Description: p-BrBzGSH(Cp)2 is an inhibitor of glyoxylase 1 (GLO1). It acts by increasing DNA-AGEs, stimulating RAGE expression, and inhibiting brain tumor growth in orthotopic mouse models.
Hodoodo Cat#: H562203
Name: p-BrBzGSH(Cp)2
CAS#: 166038-00-2
Chemical Formula: C27H38BrN3O6S
Exact Mass: 611.17
Molecular Weight: 612.580
Elemental Analysis: C, 52.94; H, 6.25; Br, 13.04; N, 6.86; O, 15.67; S, 5.23
This product is not in stock, which may be available by custom synthesis.
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Synonym: p-BrBzGSH(Cp)2; p BrBzGSH(Cp)2; pBrBzGSH(Cp)2; BBGC; BBGD;
IUPAC/Chemical Name: S-(p-Bromobenzyl) glutathione dicyclopentyl ester
InChi Key: QIFSPGPRHFNZNN-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H38BrN3O6S/c28-19-11-9-18(10-12-19)16-38-17-23(26(34)30-15-25(33)36-20-5-1-2-6-20)31-24(32)14-13-22(29)27(35)37-21-7-3-4-8-21/h9-12,20-23H,1-8,13-17,29H2,(H,30,34)(H,31,32)
SMILES Code: O=C(C(NC(CCC(C(OC1CCCC1)=O)N)=O)CSCC2=CC=C(Br)C=C2)NCC(OC3CCCC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 612.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, Shuck SC, Ciminera AK, De Jesus LR, Ouyang C, Chen MY, Termini J. Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. Int J Mol Sci. 2018 Jan 30;19(2). pii: E406. doi: 10.3390/ijms19020406. PubMed PMID: 29385725.