WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555178
CAS#: 951499-16-4
Description: GNE-3476 is a NMDA receptor PAM. GNE-3476 displayed low micromolar potency at GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing receptors.
Hodoodo Cat#: H555178
Name: GNE-3476
CAS#: 951499-16-4
Chemical Formula: C18H22N4OS
Exact Mass: 342.15
Molecular Weight: 342.461
Elemental Analysis: C, 63.13; H, 6.48; N, 16.36; O, 4.67; S, 9.36
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: GNE-3476; GNE3476; GNE 3476.
IUPAC/Chemical Name: 2-butyl-7-((ethyl(phenyl)amino)methyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
InChi Key: PTJKTJRYDXVUPM-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H22N4OS/c1-3-5-11-16-20-22-17(23)12-14(19-18(22)24-16)13-21(4-2)15-9-7-6-8-10-15/h6-10,12H,3-5,11,13H2,1-2H3
SMILES Code: O=C1C=C(CN(C2=CC=CC=C2)CC)N=C3N1N=C(CCCC)S3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 342.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Volgraf, M.; Sellers, B. D.; Jiang, Y.; Wu, G.; Ly, C. Q.; Villemure, E.; Pastor, R. M.; Yuen, P. W.; Lu, A.; Luo, X.; Liu, M.; Zhang, S.; Sun, L.; Fu, Y.; Lupardus, P. J.; Wallweber, H. J.; Liederer, B. M.; Deshmukh, G.; Plise, E.; Tay, S.; Reynen, P.; Herrington, J.; Gustafson, A.; Liu, Y.; Dirksen, A.; Dietz, M. G.; Liu, Y.; Wang, T. M.; Hanson, J. E.; Hackos, D.; Scearce-Levie, K.; Schwarz, J. B. Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): Tuning deactivation kinetics via structure-based design. J. Med. Chem. 2016, 59, 2760−2779.