Cyclobendazole

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584355

CAS#: 31431-43-3

Description: Cyclobendazole is an antihelmintic; benzimidazole derivative related to mebendazole.


Chemical Structure

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Cyclobendazole
CAS# 31431-43-3

Theoretical Analysis

Hodoodo Cat#: H584355
Name: Cyclobendazole
CAS#: 31431-43-3
Chemical Formula: C13H13N3O3
Exact Mass: 259.10
Molecular Weight: 259.265
Elemental Analysis: C, 60.23; H, 5.05; N, 16.21; O, 18.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Cyclobendazole, Ciclobendazole, Ciclobendazol, R 17147, R 17,147, CC 2481

IUPAC/Chemical Name: 2-Benzimidazolecarbamic acid, 5-(cyclopropylcarbonyl)-, methyl ester

InChi Key: OXLKOMYHDYVIDM-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13N3O3/c1-19-13(18)16-12-14-9-5-4-8(6-10(9)15-12)11(17)7-2-3-7/h4-7H,2-3H2,1H3,(H2,14,15,16,18)

SMILES Code: O=C(OC)NC1=NC2=CC(C(C3CC3)=O)=CC=C2N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brodie RR, Mayo BC, Chasseaud LF, Hawkins DR. The disposition of radioactivity after administration of the anthelminthic methyl-14C-5-cyclopropylcarbonyl-2-benzimidazole carbamate (ciclobendazole) to rats and dogs. Arzneimittelforschung. 1977;27(3):593-8. PubMed PMID: 577426.

2: Degrémont A, Stahel E. [Clinical evaluation of ciclobendazole (C-C 2481) in the treatment of colonic helminth diseases]. Schweiz Med Wochenschr. 1978 Sep 16;108(37):1430-3. German. PubMed PMID: 705298.

3: Cook GC. Use of benzimidazole chemotherapy in human helminthiases: indications and efficacy. Parasitol Today. 1990 Apr;6(4):133-6. PubMed PMID: 15463317.

4: Stürchler D, Stahel E, Saladin K, Saladin B. Intestinal parasitoses in eight Liberian settlements: prevalences and community anthelminthic chemotherapy. Tropenmed Parasitol. 1980 Mar;31(1):87-93. PubMed PMID: 7376257.

5: Guggenmoos R, Akhtaruzzaman KM, Rosenkaimer F, Gaus W, Bienzle U, Dietrich M. Comparative trial on the therapeutic effectiveness of the new anthelmintic drug: ciclobendazole. Tropenmed Parasitol. 1978 Dec;29(4):423-6. PubMed PMID: 369076.

6: Zahner H, Schares G. Experimental chemotherapy of filariasis: comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi. Acta Trop. 1993 Jan;52(4):221-66. Review. PubMed PMID: 8094587.

7: Bächlin A, Degrémont A. [Pinworm infection in kindergartens of Basel (author's transl)]. Schweiz Rundsch Med Prax. 1979 Sep 11;68(37):1183-5. German. PubMed PMID: 493246.

8: Mayo BC, Brodie RR, Chasseaud LF, Hawkins DR. Biotransformation of methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate (ciclobendazole) in rats and dogs. Drug Metab Dispos. 1978 Sep-Oct;6(5):518-27. PubMed PMID: 30601.