WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562212
CAS#: 1374128-90-1
Description: Vitacoxib is a selective COX-2 inhibitor that is used as a novel nonsteroidal anti-inflammatory agent.
Hodoodo Cat#: H562212
Name: Vitacoxib
CAS#: 1374128-90-1
Chemical Formula: C16H14ClN3O2S
Exact Mass: 347.05
Molecular Weight: 347.810
Elemental Analysis: C, 55.25; H, 4.06; Cl, 10.19; N, 12.08; O, 9.20; S, 9.22
This product is not in stock, which may be available by custom synthesis.
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Synonym: Vitacoxib;
IUPAC/Chemical Name: 2-(4-Chloro-5-(p-tolyl)-1H-imidazol-1-yl)-5-(methylsulfonyl)pyridine
InChi Key: NSWKPXFHCORWAE-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14ClN3O2S/c1-11-3-5-12(6-4-11)15-16(17)19-10-20(15)14-8-7-13(9-18-14)23(2,21)22/h3-10H,1-2H3
SMILES Code: O=S(C1=CN=C(N2C(C3=CC=C(C)C=C3)=C(Cl)N=C2)C=C1)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 347.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wang J, Li Z, Sun F, Tang S, Zhang S, Lv P, Li J, Cao X. Evaluation of dermal irritation and skin sensitization due to vitacoxib. Toxicol Rep. 2017 Jun 10;4:287-290. doi: 10.1016/j.toxrep.2017.06.003. eCollection 2017. PubMed PMID: 28959651; PubMed Central PMCID: PMC5615138.
2: Wang J, Zhao T, Kong J, Peng H, Lv P, Li J, Cao X, Zhang S. Determination of vitacoxib, a novel COX-2 inhibitor, in equine plasma using UPLC-MS/MS detection: Development and validation of new methodology. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:270-274. doi: 10.1016/j.jchromb.2017.07.024. Epub 2017 Jul 15. PubMed PMID: 28759842.
3: Wang J, Sun F, Tang S, Zhang S, Lv P, Li J, Cao X. Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies. Regul Toxicol Pharmacol. 2017 Jun;86:49-58. doi: 10.1016/j.yrtph.2017.02.020. Epub 2017 Feb 24. PubMed PMID: 28238853.