WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562221
CAS#: 1033040-23-1
Description: TPO-Agonist-1 is a potent and selective thrombopoietin (TPO) receptor agonist.
Hodoodo Cat#: H562221
Name: TPO-Agonist-1
CAS#: 1033040-23-1
Chemical Formula: C25H22N8O2
Exact Mass: 466.19
Molecular Weight: 466.500
Elemental Analysis: C, 64.37; H, 4.75; N, 24.02; O, 6.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: TPO-Agonist-1; TPO Agonist 1; TPOAgonist1;
IUPAC/Chemical Name: 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazole-4,5-dione 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone]
InChi Key: IIBBJCNVTRCTDV-HPNDGRJYSA-N
InChi Code: InChI=1S/C25H22N8O2/c1-14-10-11-19(12-15(14)2)33-25(35)22(16(3)30-33)27-26-21-9-5-8-20(23(21)34)17-6-4-7-18(13-17)24-28-31-32-29-24/h4-13,26,34H,1-3H3,(H,28,29,31,32)/b27-22+
SMILES Code: O=C(N(C1=CC=C(C)C(C)=C1)N=C/2C)C2=N\NC3=C(O)C(C4=CC=CC(C5=NNN=N5)=C4)=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 466.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Perdomo J. Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia. Immunotargets Ther. 2016 Feb 22;5:1-7. doi: 10.2147/ITT.S80648. eCollection 2016. Review. PubMed PMID: 27529057; PubMed Central PMCID: PMC4970631.
2: Kuter DJ. The biology of thrombopoietin and thrombopoietin receptor agonists. Int J Hematol. 2013 Jul;98(1):10-23. doi: 10.1007/s12185-013-1382-0. Epub 2013 Jul 3. Review. PubMed PMID: 23821332.
3: Zeng Y, Duan X, Xu J, Ni X. TPO receptor agonist for chronic idiopathic thrombocytopenic purpura. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008235. doi: 10.1002/14651858.CD008235.pub2. Review. PubMed PMID: 21735426.
4: Cohn CS, Bussel JB. Romiplostim: a second-generation thrombopoietin agonist. Drugs Today (Barc). 2009 Mar;45(3):175-88. doi: 10.1358/dot.2009.45.3.1343793. Review. PubMed PMID: 19436840.
5: Harker LA. Therapeutic cytokine stimulation of thrombocytopoiesis. Transfus Sci. 1998 Jun;19(2):149-62. Review. PubMed PMID: 10187040.