WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562234
CAS#: 19956-54-8
Description: Methyllucidone is a STAT3 inhibitor. It acts by regulating the expression of the protein tyrosine phosphatase MEG2.
Hodoodo Cat#: H562234
Name: Methyllucidone
CAS#: 19956-54-8
Chemical Formula: C16H14O4
Exact Mass: 270.09
Molecular Weight: 270.280
Elemental Analysis: C, 71.10; H, 5.22; O, 23.68
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Synonym: Methyllucidone;
IUPAC/Chemical Name: (2Z)-4-Methoxy-2-[(E)-1-methoxy-3-phenylprop-2-enylidene]cyclopent-4-ene-1,3-dione
InChi Key: FITVJPYUOAZKPN-PBMBQWDMSA-N
InChi Code: InChI=1S/C16H14O4/c1-19-13(9-8-11-6-4-3-5-7-11)15-12(17)10-14(20-2)16(15)18/h3-10H,1-2H3/b9-8+,15-13-
SMILES Code: O=C1/C(C(C(OC)=C1)=O)=C(OC)\C=C\C2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 270.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Jin Y, Kim YH, Park JY, Lee YJ, Oh HM, Choi SK, Han DC, Kwon BM. Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells. Bioorg Med Chem Lett. 2018 Mar 1;28(5):853-857. doi: 10.1016/j.bmcl.2018.02.012. Epub 2018 Feb 8. PubMed PMID: 29456111.
2: Cui Y, Wu J, Jung SC, Kim GO, Kyeong Ko R, Lee HJ, Yoo ES, Kang HK, Suk K, Eun SY. Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity. Eur J Pharmacol. 2012 Sep 5;690(1-3):4-12. doi: 10.1016/j.ejphar.2012.05.041. Epub 2012 Jun 7. PubMed PMID: 22683871.
3: Oh HM, Choi SK, Lee JM, Lee SK, Kim HY, Han DC, Kim HM, Son KH, Kwon BM. Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino. Bioorg Med Chem. 2005 Nov 15;13(22):6182-7. Epub 2005 Aug 1. PubMed PMID: 16055336.