WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562243
CAS#: 878451-87-7
Description: RS-246204 is a small molecule R-spondin-1 substitute. It acts by promoting the initial formation and growth of enteroids in the medium without R-spondin-1.
Hodoodo Cat#: H562243
Name: RS-246204
CAS#: 878451-87-7
Chemical Formula: C16H13N5O2S
Exact Mass: 339.08
Molecular Weight: 339.370
Elemental Analysis: C, 56.63; H, 3.86; N, 20.64; O, 9.43; S, 9.45
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Synonym: RS-246204; RS 246204; RS246204;
IUPAC/Chemical Name: 3,7-Dimethyl-8-(quinolin-2-ylthio)-3,7-dihydro-1H-purine-2,6-dione
InChi Key: UHUHSGFUUWVRBO-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13N5O2S/c1-20-12-13(21(2)15(23)19-14(12)22)18-16(20)24-11-8-7-9-5-3-4-6-10(9)17-11/h3-8H,1-2H3,(H,19,22,23)
SMILES Code: O=C(N1)N(C)C2=C(N(C)C(SC3=NC4=CC=CC=C4C=C3)=N2)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 339.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Nam MO, Hahn S, Jee JH, Hwang TS, Yoon H, Lee DH, Kwon MS, Yoo J. Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget. 2017 Dec 26;9(5):6356-6368. doi: 10.18632/oncotarget.23721. eCollection 2018 Jan 19. PubMed PMID: 29464078; PubMed Central PMCID: PMC5814218.