Nafiverine

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581125

CAS#: 5061-22-3

Description: Nafiverine is a new antispasmodic. The stability of nafiverine, in an aqueous solution and in rabbit plasma was investigated. Metabolites of nafiverine in blood, bile, and urine were determined quantitatively. The effectiveness of an intramuscular administration of nafiverine was comparable to that of an intravenous administration. One metabolite of nafiverine, N-(2-hydroxyethyl)-N'-[alpha-(naphthyl)propionyloxy-2-ethyl]piperazine, is a new compound.

Chemical Structure

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Nafiverine
CAS# 5061-22-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H581125
Name: Nafiverine
CAS#: 5061-22-3
Chemical Formula: C30H22N4O4
Exact Mass: 502.16
Molecular Weight: 502.530
Elemental Analysis: C, 71.70; H, 4.41; N, 11.15; O, 12.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Nafiverine; Nafiverinum; Nafiverina; Nafiverinum [INN-Latin]; UNII-WLT400RC9Q; EINECS 225-766-5;

IUPAC/Chemical Name: 2,2'-(1,4-Piperazindiyl)diethylbis(alpha-methyl-1-naphthalinacetat)

InChi Key: USKAVCMWCUTATL-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H22N4O4/c35-27-25(28(36)32(22-15-7-2-8-16-22)31(27)21-13-5-1-6-14-21)26-29(37)33(23-17-9-3-10-18-23)34(30(26)38)24-19-11-4-12-20-24/h1-20,25-26H

SMILES Code: O=C(C1C2C(N(C3=CC=CC=C3)N(C4=CC=CC=C4)C2=O)=O)N(C5=CC=CC=C5)N(C6=CC=CC=C6)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 502.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Naito S, Yamamoto T. Stability, absorption, excretion, and distribution of nafiverine. J Pharm Sci. 1975 Feb;64(2):253-8. PubMed PMID: 1127581.

2: Ramu A, Ramu N. Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds. Cancer Chemother Pharmacol. 1994;34(5):423-30. PubMed PMID: 8070010.