WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584370
CAS#: 81-13-0
Description: Dexpanthenol seems to have antiinflammatory and antioxidant properties. Prophylaxis with Dexpanthenol has a potential to reduce the severity of intestinal damage in necrotizing enterocolitis in the animals.
Hodoodo Cat#: H584370
Name: Dexpanthenol
CAS#: 81-13-0
Chemical Formula: C9H19NO4
Exact Mass: 205.13
Molecular Weight: 205.254
Elemental Analysis: C, 52.67; H, 9.33; N, 6.82; O, 31.18
Synonym: Dexpanthenol; EC 201-327-3; D-Panthenol; Bepantol
IUPAC/Chemical Name: Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-
InChi Key: SNPLKNRPJHDVJA-ZETCQYMHSA-N
InChi Code: InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1
SMILES Code: O=C(NCCCO)[C@H](O)C(C)(C)CO
Appearance: Clear liquid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. |
| In vitro activity: | Dexpanthenol significantly reduces the toxic effects of xylometazoline regarding cell growth (p < 0.001) when applied in advance. When dexpanthenol is therapeutically applied after xylometazoline, effects on cell growth are only one-half of those of the protective approach. Reference: Am J Rhinol. 2004 Sep-Oct;18(5):315-20. https://pubmed.ncbi.nlm.nih.gov/15586804/ |
| In vivo activity: | Twenty-seven rats were randomly divided into 3 groups containing 9 rats each. The 1st group comprised the sham group with no procedure performed. The 2nd group had only torsion applied, while the 3rd group had torsion + dexpanthenol applied. The torsion + dexpanthenol group was identified to have more preservation of testis function observed histologically and hormonally compared to the torsion group. Reference: J Pediatr Urol. 2021 Apr 8:S1477-5131(21)00201-1. https://pubmed.ncbi.nlm.nih.gov/33883095/ |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.0 | 160.78 | |
| Ethanol | 110.0 | 535.92 |
The following data is based on the product molecular weight 205.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Klöcker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol. 2004 Sep-Oct;18(5):315-20. PMID: 15586804. 2. Aydın A, Sönmez MG, Ecer G, Kılınç F, Kocabaş R, Atılgan AE, Oltulu P, Balasar M. The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia/reperfusion injury. J Pediatr Urol. 2021 Apr 8:S1477-5131(21)00201-1. doi: 10.1016/j.jpurol.2021.03.031. Epub ahead of print. PMID: 33883095. 3. Erdogan MA, Yigitturk G, Erbas O, Taskıran D. Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats. Drug Chem Toxicol. 2021 Apr 20:1-9. doi: 10.1080/01480545.2021.1914464. Epub ahead of print. PMID: 33874839. |
| In vitro protocol: | 1. Klöcker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol. 2004 Sep-Oct;18(5):315-20. PMID: 15586804. |
| In vivo protocol: | 1. Aydın A, Sönmez MG, Ecer G, Kılınç F, Kocabaş R, Atılgan AE, Oltulu P, Balasar M. The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia/reperfusion injury. J Pediatr Urol. 2021 Apr 8:S1477-5131(21)00201-1. doi: 10.1016/j.jpurol.2021.03.031. Epub ahead of print. PMID: 33883095. 2. Erdogan MA, Yigitturk G, Erbas O, Taskıran D. Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats. Drug Chem Toxicol. 2021 Apr 20:1-9. doi: 10.1080/01480545.2021.1914464. Epub ahead of print. PMID: 33874839. |
1: Oguz A, Uslukaya O, Alabalık U, Turkoglu A, Kapan M, Bozdag Z. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015 Apr;100(4):656-61. doi: 10.9738/INTSURG-D-14-00227.1. Epub 2015 Jan 13. PubMed PMID: 25583306; PubMed Central PMCID: PMC4400934.
2: Yardimci I, Karakan T, Resorlu B, Doluoglu OG, Ozcan S, Aydın A, Demirbas A, Unverdi H, Eroglu M. The effect of intraurethral dexpanthenol on healing and fibrosis in rats with experimentally induced urethral trauma. Urology. 2015 Jan;85(1):274.e9-13. doi: 10.1016/j.urology.2014.09.038. PubMed PMID: 25530405.
3: Lopez-Lopez J, Jan-Pallí E, lez-Navarro BG, Jané-Salas E, Estrugo-Devesa A, Milani M. Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. Curr Med Res Opin. 2015 Dec;31(12):2179-83. doi: 10.1185/03007995.2015.1108909. Epub 2015 Nov 4. Erratum in: Curr Med Res Opin. 2016;32(2):395. Lope-Lopez, Jose [corrected to Lopez-Lopez, Jose]; González-Navarro, Beatriz [corrected to lez-Navarro, Beatriz Gonzá]. PubMed PMID: 26471464.
4: Koç ZP, İn E, Karslioğlu İ, Üçer Ö, Canpolat S. Evaluation of the preventive effect of dexpanthenol in radiation injury by lung perfusion scintigraphy: a preclinical experimental model of radiation injury. Nucl Med Commun. 2015 Dec;36(12):1227-32. doi: 10.1097/MNM.0000000000000392. PubMed PMID: 26509715.
5: Hsu KH, de la Jara PL, Ariyavidana A, Watling J, Holden B, Garrett Q, Chauhan A. Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses. Curr Eye Res. 2015 Mar;40(3):267-73. doi: 10.3109/02713683.2014.917192. Epub 2014 May 15. PubMed PMID: 24833321.
6: Celebi S, Tepe C, Yelken K, Celik O. Efficacy of dexpanthenol for pediatric post-tonsillectomy pain and wound healing. Ann Otol Rhinol Laryngol. 2013 Jul;122(7):464-7. PubMed PMID: 23951700.
7: Karadag A, Ozdemir R, Kurt A, Parlakpinar H, Polat A, Vardi N, Taslidere E, Karaman A. Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis. J Pediatr Surg. 2015 Jul;50(7):1119-24. doi: 10.1016/j.jpedsurg.2014.10.053. Epub 2014 Nov 7. PubMed PMID: 25783305.
8: Heise R, Skazik C, Marquardt Y, Czaja K, Sebastian K, Kurschat P, Gan L, Denecke B, Ekanayake-Bohlig S, Wilhelm KP, Merk HF, Baron JM. Dexpanthenol modulates gene expression in skin wound healing in vivo. Skin Pharmacol Physiol. 2012;25(5):241-8. doi: 10.1159/000341144. Epub 2012 Jun 29. PubMed PMID: 22759998.
9: Censabella S, Claes S, Orlandini M, Braekers R, Thijs H, Bulens P. Retrospective study of radiotherapy-induced skin reactions in breast cancer patients: reduced incidence of moist desquamation with a hydroactive colloid gel versus dexpanthenol. Eur J Oncol Nurs. 2014 Oct;18(5):499-504. doi: 10.1016/j.ejon.2014.04.009. Epub 2014 May 28. PubMed PMID: 24877859.
10: Shanazi M, Farshbaf Khalili A, Kamalifard M, Asghari Jafarabadi M, Masoudin K, Esmaeli F. Comparison of the Effects of Lanolin, Peppermint, and Dexpanthenol Creams on Treatment of Traumatic Nipples in Breastfeeding Mothers. J Caring Sci. 2015 Dec 1;4(4):297-307. doi: 10.15171/jcs.2015.030. eCollection 2015 Dec. PubMed PMID: 26744729; PubMed Central PMCID: PMC4699508.
11: De AK, Chowdhury PP, Chattapadhyay S. Simultaneous Quantification of Dexpanthenol and Resorcinol from Hair Care Formulation Using Liquid Chromatography: Method Development and Validation. Scientifica (Cairo). 2016;2016:1537952. doi: 10.1155/2016/1537952. Epub 2016 Mar 3. PubMed PMID: 27042377; PubMed Central PMCID: PMC4794562.
12: Björklund S, Pham QD, Jensen LB, Knudsen NØ, Nielsen LD, Ekelund K, Ruzgas T, Engblom J, Sparr E. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. J Colloid Interface Sci. 2016 Oct 1;479:207-20. doi: 10.1016/j.jcis.2016.06.054. Epub 2016 Jun 23. PubMed PMID: 27388135.
13: Gulle K, Ceri NG, Akpolat M, Arasli M, Demirci B. The effects of dexpanthenol in streptozotocin-induced diabetic rats: histological, histochemical and immunological evidences. Histol Histopathol. 2014 Oct;29(10):1305-13. doi: 10.14670/HH-29.1305. Epub 2014 Apr 14. PubMed PMID: 24733664.
14: Ulger BV, Kapan M, Uslukaya O, Bozdag Z, Turkoglu A, Alabalık U, Onder A. Comparing the effects of nebivolol and dexpanthenol on wound healing: an experimental study. Int Wound J. 2016 Jun;13(3):367-71. doi: 10.1111/iwj.12314. Epub 2014 Jul 15. PubMed PMID: 25040679.
15: Sen H, Deniz S, Yedekci AE, Inangil G, Muftuoglu T, Haholu A, Ozkan S. Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury. Ren Fail. 2014 Nov;36(10):1570-4. doi: 10.3109/0886022X.2014.949768. Epub 2014 Aug 26. PubMed PMID: 25156619.
16: Kramer A, Assadian O, Koburger-Janssen T. Antimicrobial efficacy of the combination of chlorhexidine digluconate and dexpanthenol. GMS Hyg Infect Control. 2016 Dec 14;11:Doc24. doi: 10.3205/dgkh000284. eCollection 2016. PubMed PMID: 27999767; PubMed Central PMCID: PMC5156840.
17: Gulec AI, Albayrak H, Uslu E, Başkan E, Aliagaoglu C. Pustular irritant contact dermatitis caused by dexpanthenol in a child. Cutan Ocul Toxicol. 2015 Mar;34(1):75-6. doi: 10.3109/15569527.2014.883405. Epub 2014 Feb 10. PubMed PMID: 24506320.
18: Turgut O, Ay AA, Turgut H, Ay A, Kafkas S, Dost T. Effects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized rats. Age (Dordr). 2013 Dec;35(6):2229-35. doi: 10.1007/s11357-013-9519-x. Epub 2013 Mar 8. PubMed PMID: 23471492; PubMed Central PMCID: PMC3825017.
19: Ermis H, Parlakpinar H, Gulbas G, Vardi N, Polat A, Cetin A, Kilic T, Aytemur ZA. Protective effect of dexpanthenol on bleomycin-induced pulmonary fibrosis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1103-10. doi: 10.1007/s00210-013-0908-6. Epub 2013 Aug 31. PubMed PMID: 23995256.
20: Bayrak O, Seckiner I, Solakhan M, Karakok M, Erturhan SM, Yagci F. Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model. Urology. 2012 May;79(5):1023-6. doi: 10.1016/j.urology.2012.01.025. PubMed PMID: 22546378.
