WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527785
CAS#: 108477-18-5
Description: NSC-144303 is a potent inhibitor of general DUB activity leading to acute proteotoxicstress and apoptosis.
Hodoodo Cat#: H527785
Name: NSC-144303
CAS#: 108477-18-5
Chemical Formula: C19H14N2O7S
Exact Mass: 414.05
Molecular Weight: 414.388
Elemental Analysis: C, 55.07; H, 3.41; N, 6.76; O, 27.03; S, 7.74
Synonym: NSC-144303; NSC144303; NSC 144303; G5
IUPAC/Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one 1,1-dioxide
InChi Key: SSAMIOWVUGBIJK-KAVGSWPWSA-N
InChi Code: InChI=1S/C19H14N2O7S/c22-19-15(9-13-1-5-17(6-2-13)20(23)24)11-29(27,28)12-16(19)10-14-3-7-18(8-4-14)21(25)26/h1-10H,11-12H2/b15-9+,16-10+
SMILES Code: O=C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)/C(CS1(=O)=O)=C/C3=CC=C([N+]([O-])=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 414.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Aleo E, Henderson CJ, Fontanini A, Solazzo B, Brancolini C. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44. PubMed PMID: 16982768.