WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562287
CAS#: 1680196-54-6
Description: FzM1 is the first allosteric ligand of Frizzled4, a member of the Fzd family of Wnt receptors. It acts by specifically signaling downstream of Wnt5a to promote dendrite branching and growth.
Hodoodo Cat#: H562287
Name: FzM1
CAS#: 1680196-54-6
Chemical Formula: C21H16N2O2S
Exact Mass: 360.09
Molecular Weight: 360.430
Elemental Analysis: C, 69.98; H, 4.47; N, 7.77; O, 8.88; S, 8.89
Synonym: FzM1; FzM-1; FzM 1;
IUPAC/Chemical Name: 1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea
InChi Key: OBTSACXGWYGCPK-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25)
SMILES Code: O=C(NC1=CC=C2C=CC=CC2=C1)NC3=CC(C4=CC=CS4)=CC(O)=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 360.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E, Stornaiuolo M. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851. doi: 10.1021/acs.biochem.7b01087. Epub 2018 Jan 19. PubMed PMID: 29293331.