WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562301
CAS#: 1103745-28-3
Description: TM-233 is an inhibitor of both JAK/STAT and proteasome activities. It acts by inducing cell death in myeloma cells.
Hodoodo Cat#: H562301
Name: TM-233
CAS#: 1103745-28-3
Chemical Formula: C25H20O4
Exact Mass: 384.14
Molecular Weight: 384.430
Elemental Analysis: C, 78.11; H, 5.24; O, 16.65
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Synonym: TM-233; TM 233; TM233;
IUPAC/Chemical Name: 4-Acetoxy-alpha-(9'-anthracenyl)benzyl Acetate
InChi Key: OJRIRVRRVVNDHU-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H20O4/c1-16(26)28-21-13-11-18(12-14-21)25(29-17(2)27)24-22-9-5-3-7-19(22)15-20-8-4-6-10-23(20)24/h3-15,25H,1-2H3
SMILES Code: CC(OC(C1=C2C=CC=CC2=CC3=CC=CC=C13)C4=CC=C(OC(C)=O)C=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 384.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sagawa M, Tabayashi T, Kimura Y, Tomikawa T, Nemoto-Anan T, Watanabe R, Tokuhira M, Ri M, Hashimoto Y, Iida S, Kizaki M. TM-233, a novel analog of 1'-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities. Cancer Sci. 2015 Apr;106(4):438-46. doi: 10.1111/cas.12616. Epub 2015 Mar 10. PubMed PMID: 25613668; PubMed Central PMCID: PMC4409888.