WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555194
CAS#: 1166398-85-1
Description: Radamide is a Grp94 inhibitor.
Hodoodo Cat#: H555194
Name: Radamide
CAS#: 1166398-85-1
Chemical Formula: C18H18ClNO8
Exact Mass: 411.07
Molecular Weight: 411.791
Elemental Analysis: C, 52.50; H, 4.41; Cl, 8.61; N, 3.40; O, 31.08
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Synonym: Radamide
IUPAC/Chemical Name: ethyl 3-chloro-2-(2-((2,5-dihydroxy-4-methoxyphenyl)amino)-2-oxoethyl)-4,6-dihydroxybenzoate
InChi Key: RULSXWFZXUOCOD-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18ClNO8/c1-3-28-18(26)16-8(17(19)13(24)6-12(16)23)4-15(25)20-9-5-11(22)14(27-2)7-10(9)21/h5-7,21-24H,3-4H2,1-2H3,(H,20,25)
SMILES Code: O=C(OCC)C1=C(O)C=C(O)C(Cl)=C1CC(NC2=CC(O)=C(OC)C=C2O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 411.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. J Med Chem. 2016 Apr 14;59(7):3471-88. doi: 10.1021/acs.jmedchem.6b00085. Epub 2016 Apr 4. PubMed PMID: 27003516; PubMed Central PMCID: PMC4979570.
2: Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS. Development of radamide analogs as Grp94 inhibitors. Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12. PubMed PMID: 25027801; PubMed Central PMCID: PMC4142655.
3: Hadden MK, Blagg BS. Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. J Org Chem. 2009 Jul 3;74(13):4697-704. doi: 10.1021/jo900278g. PubMed PMID: 19492825; PubMed Central PMCID: PMC2844856.
4: Immormino RM, Metzger LE 4th, Reardon PN, Dollins DE, Blagg BS, Gewirth DT. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J Mol Biol. 2009 May 22;388(5):1033-42. doi: 10.1016/j.jmb.2009.03.071. Epub 2009 Apr 8. PubMed PMID: 19361515; PubMed Central PMCID: PMC2692672.
5: Clevenger RC, Blagg BS. Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide. Org Lett. 2004 Nov 25;6(24):4459-62. PubMed PMID: 15548050.
