Phenylbutazone sodium

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581144

CAS#: 129-18-0 (sodium)

Description: Phenylbutazone sodium has anti-inflammatory effects.


Chemical Structure

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Phenylbutazone sodium
CAS# 129-18-0 (sodium)

Theoretical Analysis

Hodoodo Cat#: H581144
Name: Phenylbutazone sodium
CAS#: 129-18-0 (sodium)
Chemical Formula: C19H20N2NaO2
Exact Mass: 331.14
Molecular Weight: 331.370
Elemental Analysis: C, 68.87; H, 6.08; N, 8.45; Na, 6.94; O, 9.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 70145-60-7 (calcium)   129-18-0 (sodium)   50-33-9 (free form)    

Synonym: Phenylbutazone sodium; Phenylbutazone sodium salt; Sodium phenylbutazone; Sodium butazolidine;

IUPAC/Chemical Name: sodium 4-butyl-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrazol-3-olate

InChi Key: NNFXVGOLTQESMQ-UHFFFAOYSA-M

InChi Code: InChI=1S/C19H20N2O2.Na/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;/h4-13,22H,2-3,14H2,1H3;/q;+1/p-1

SMILES Code: CCCCC1=C(O[Na])N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 331.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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9: CHITI E, MALERBA G. [Phenylbutazone and water-electrolyte metabolism; modifications of the electrolytes, sodium potassium and chlorine, after administration of phenylbutazone in normal subjects]. Arch Maragliano Patol Clin. 1955 Jun;10(3):1259-71. Italian. PubMed PMID: 13269250.

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15: YU TF, BURNS JJ, PATON BC, GUTMAN AB, BRODIE BB. Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man. J Pharmacol Exp Ther. 1958 May;123(1):63-9. PubMed PMID: 13539792.

16: Ichibagase H, Imamura Y, Kinoshita A, Kojima S. Effects of simultaneous administration of drugs on absorption and excretion. I. Effect of phenylbutazone on absorption and excretion of sodium cyclamate in rabbits. Chem Pharm Bull (Tokyo). 1972 May;20(5):947-52. PubMed PMID: 5055125.

17: Doherty TJ, Andrews FM, Blackford JT, Rohrbach BW, Sandin A, Saxton AM. Effects of lipopolysaccharide and phenylbutazone on gastric contents in the horse. Equine Vet J. 2003 Jul;35(5):472-5. PubMed PMID: 12875325.

18: YU TF, BURNS JJ, DAYTON PG, GUTMAN AB, BRODIE BB. A p-nitro analogue of phenylbutazone possessing potent antirheumatic, sodium retaining and uricosuric properties. J Pharmacol Exp Ther. 1959 Jul;126(3):185-9. PubMed PMID: 13673366.

19: Bakkali A, Corta E, Berrueta LA, Gallo B, Vicente F. Study of the solid-phase extraction of diclofenac sodium, indomethacin and phenylbutazone for their analysis in human urine by liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Jun 11;729(1-2):139-45. PubMed PMID: 10410936.

20: Dyke TM, Hinchcliff KW, Sams RA. Attenuation by phenylbutazone of the renal effects and excretion of frusemide in horses. Equine Vet J. 1999 Jul;31(4):289-95. PubMed PMID: 10454086.