WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H581143
CAS#: 70145-60-7 (calcium)
Description: Phenylbutazone calcium is calcium derivative of phenylbutazone. it has anti-inflammatory effects,
Hodoodo Cat#: H581143
Name: Phenylbutazone calcium
CAS#: 70145-60-7 (calcium)
Chemical Formula: C38H38CaN4O4
Exact Mass: 0.00
Molecular Weight: 654.824
Elemental Analysis: C, 69.70; H, 5.85; Ca, 6.12; N, 8.56; O, 9.77
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Related CAS #: 70145-60-7 (calcium) 129-18-0 (sodium) 50-33-9 (free form)
Synonym: Phenylbutazone calcium; DA-241; DA241; DA 241; P 241; Phenylbutazone calcium salt;
IUPAC/Chemical Name: calcium 4-butyl-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrazol-3-olate
InChi Key: XMVFRSAMWBGRNR-UHFFFAOYSA-L
InChi Code: InChI=1S/2C19H20N2O2.Ca/c2*1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;/h2*4-13,22H,2-3,14H2,1H3;/q;;+2/p-2
SMILES Code: [O-]C1=C(CCCC)C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O.[O-]C4=C(CCCC)C(N(C5=CC=CC=C5)N4C6=CC=CC=C6)=O.[Ca+2]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 654.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Hanada S, Mengardo S, Oga S. Bioavailability and anti-inflammatory effects of phenylbutazone sodium and phenylbutazone calcium in rats. Boll Chim Farm. 1987 May;126(5):203-7. PubMed PMID: 3450309.
2: Neuschl J, Kohút A. [Effect of amitriptyline on the ulcerogenic action of phenylbutazone and reserpine with respect to calcium levels in the stomach wall and blood in rats of different ages (author's transl)]. Bratisl Lek Listy. 1979 Feb;71(2):173-8. Slovak. PubMed PMID: 427612.
3: Carlassare M. [Calcium phenylbutazone]. Boll Chim Farm. 1971 Sep;110(9):510-4. Italian. PubMed PMID: 5137988.
4: BAUST W, KRAATZ HG. [A calcium-like effect of phenylbutazone (butazolidin)]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;232(3):562-72. German. PubMed PMID: 13552733.
5: RATTI G. [Calcium derivative of phenylbutazone]. Reumatismo. 1957;9(Suppl 1):95-7. Italian. PubMed PMID: 13441980.
6: Neuschl J, Kohút A, Nicák A. [The effect of calcium chloride on the ulcerogenic effects of phenylbutazone and reserpine in relation to the calcium content of the stomach wall in rats of various ages]. Cesk Gastroenterol Vyz. 1983 Mar;37(2):98-102. Slovak. PubMed PMID: 6850876.
7: Spilberg I, Gallacher A, Mandell B, Rosenberg D. A mechanism of action for non-steroidal anti-inflammatory agents in calcium pyrophosphate dihydrate (CPPD) crystal induced arthritis. Agents Actions. 1977 Mar;7(1):153-5. PubMed PMID: 193386.
8: SPILDBORGHS G, NEBO F. [Evaluation of the use of the calcium salt of phenylbutazone in rheumatoid arthritis in adults]. Rev Bras Med. 1957 Dec;14(12):859-61. Portuguese. PubMed PMID: 13568199.
9: MARINI A, PICENI-SERENI L. [Use of phenylbutazone calcium salt (P 241) in the treatment of rheumatic fever in childhood]. Arcisp S Anna Ferrara. 1956;9(3):461-90. Italian. PubMed PMID: 13355641.
10: Neuschl J, Kohút A, Nicák A. [Influence of nialamide on the ulcerogenic action of phenylbutazone and reserpine in relation to calcium levels in the gastric wall and blood of rats of different age (author's transl)]. Cesk Gastroenterol Vyz. 1979 Jun;33(4):191-5. Slovak. PubMed PMID: 509570.
11: STENGER EG. [Antiphlogistic effect of phenylbutazone in calcium cyanide-, monoiodo-acetic acid- and sodium fluoride-induced edema of rat paw]. Arzneimittelforschung. 1958 Sep;8(9):622. German. PubMed PMID: 13607284.
12: Lin K, Sadée W, Quillan JM. Rapid measurements of intracellular calcium using a fluorescence plate reader. Biotechniques. 1999 Feb;26(2):318-22, 324-6. PubMed PMID: 10023544.
13: Hansson L, Huunan-Seppälä A, Mattila A. The content of calcium, magnesium, copper, zinc, lead and chromium in the blood of patients with rheumatoid arthritis. Scand J Rheumatol. 1975;4(1):33-8. PubMed PMID: 1153978.
14: Parkinson N, Bolsover S, Mason W. Nuclear and cytosolic calcium changes in osteoclasts stimulated with ATP and integrin-binding peptide. Cell Calcium. 1998 Sep;24(3):213-21. PubMed PMID: 9883275.
15: Neuschl J. [Relation of nonsteroidal anti-inflammatory agents and reserpine to calcium homeostasis]. Cesk Farm. 1987 Sep;36(7):312-6. Slovak. PubMed PMID: 3664648.
16: Denko CW, Whitehouse MW. Experimental inflammation induced by naturally occurring microcrystalline calcium salts. J Rheumatol. 1976 Mar;3(1):54-62. PubMed PMID: 1271389.
17: Spahn H, Mutschler E, Geissler HE, Faust-Tinnefeldt G. [Comparison of bumadizone-, phenylbutazone- and oxyphenbutazone-plasma levels after a single oral dose of phenylbutazone and of bumadizone, respectively (author's transl)]. Arzneimittelforschung. 1981;31(3):499-503. German. PubMed PMID: 6894380.
18: Breull W, Karzel K. Influence of phenylbutazone on the membrane resting potential of frog skeletal muscle fibres in vitro. Pharmacology. 1970;4(1):25-32. PubMed PMID: 5431770.
19: Neuschl J, Kohút A, Nicák A. [The relationship between the levels of calcium on the stomach wall and in the blood and ulcerogenic effect of phenylbutazone and reserpine in intact, adrenalectomized and vagotomized rats of various age (author's transl)]. Cesk Gastroenterol Vyz. 1978 Mar;32(2):85-90. Slovak. PubMed PMID: 657308.
20: Snow DH, Bogan JA, Douglas TA, Thompson H. Phenylbutazone toxicity in ponies. Vet Rec. 1979 Jul 14;105(2):26-30. PubMed PMID: 555115.
