WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562342
CAS#: 1802665-43-5
Description: BPTQ is a typical intercalator of DNA. It acts by inducing dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at S and G2/M phase and activating the mitochondria-mediated apoptosis pathway.
Hodoodo Cat#: H562342
Name: BPTQ
CAS#: 1802665-43-5
Chemical Formula: C17H16N4S
Exact Mass: 308.11
Molecular Weight: 308.400
Elemental Analysis: C, 66.21; H, 5.23; N, 18.17; S, 10.40
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Synonym: BPTQ; B-P-T-Q;
IUPAC/Chemical Name: 4-Butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline
InChi Key: HNUWBMCYWQHNIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H16N4S/c1-2-3-8-18-16-15-14(19-10-20-16)12-9-11-6-4-5-7-13(11)21-17(12)22-15/h4-7,9-10H,2-3,8H2,1H3,(H,18,19,20)
SMILES Code: CCCCNC1=C2C(C3=CC4=CC=CC=C4N=C3S2)=NC=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 308.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Rohit Kumar H, Kumar CS, Kiran Kumar HN, Advi Rao GM. Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline. Acta Pharm Sin B. 2017 May;7(3):303-310. doi: 10.1016/j.apsb.2017.01.001. Epub 2017 Mar 7. PubMed PMID: 28540166; PubMed Central PMCID: PMC5430831.
2: RohitKumar HG, Asha KR, Raghavan SC, Advi Rao GM. DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells. Cancer Chemother Pharmacol. 2015 Jun;75(6):1121-33. doi: 10.1007/s00280-015-2735-6. Epub 2015 Mar 29. PubMed PMID: 25819915.