AMDE-1

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562380

CAS#: 478043-30-0

Description: AMDE-1 is a modulator of autophagy activity. It acts by triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation.

Chemical Structure

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AMDE-1
CAS# 478043-30-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H562380
Name: AMDE-1
CAS#: 478043-30-0
Chemical Formula: C18H8ClF6N3
Exact Mass: 415.03
Molecular Weight: 415.720
Elemental Analysis: C, 52.01; H, 1.94; Cl, 8.53; F, 27.42; N, 10.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AMDE-1; AMDE 1; AMDE1; Autophagy Modulator with Dual Effect-1;

IUPAC/Chemical Name: alpha-(3-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile

InChi Key: QPWWAOMXYPIDOY-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H8ClF6N3/c19-10-3-1-2-9(6-10)12(8-26)14-5-4-11-13(17(20,21)22)7-15(18(23,24)25)28-16(11)27-14/h1-7,12H

SMILES Code: N#CC(C1=CC=CC(Cl)=C1)C2=NC3=NC(C(F)(F)F)=CC(C(F)(F)F)=C3C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 415.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gao Y, Liu Y, Hong L, Yang Z, Cai X, Chen X, Fu Y, Lin Y, Wen W, Li S, Liu X, Huang H, Vogt A, Liu P, Yin XM, Li M. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330. doi: 10.1038/cddis.2016.236. PubMed PMID: 27512951; PubMed Central PMCID: PMC5108321.

2: Li M, Yang Z, Vollmer LL, Gao Y, Fu Y, Liu C, Chen X, Liu P, Vogt A, Yin XM. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083. doi: 10.1371/journal.pone.0122083. eCollection 2015. PubMed PMID: 25894744; PubMed Central PMCID: PMC4403922.