Oxethazaine
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584386

CAS#: 126-27-2

Description: Oxethazaine is a surface anesthetic used mainly orally in chronic gastritis & heartburn to analgize the gastric mucosa.

Chemical Structure

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Oxethazaine
CAS# 126-27-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H584386
Name: Oxethazaine
CAS#: 126-27-2
Chemical Formula: C28H41N3O3
Exact Mass: 467.31
Molecular Weight: 467.654
Elemental Analysis: C, 71.91; H, 8.84; N, 8.99; O, 10.26

Price and Availability

Size Price Availability Quantity
5g USD 265 2 Weeks
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Synonym: Oxethazaine; WY 806; Wy-806; Oxetacaine; Emoren; FH 099; Milzine; Mucaine; Mucoxin; Muthesa

IUPAC/Chemical Name: Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(1,1-dimethyl-2-phenylethyl)-N-methyl-

InChi Key: FTLDJPRFCGDUFH-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

SMILES Code: OCCN(CC(N(C(C)(C)CC1=CC=CC=C1)C)=O)CC(N(C(C)(C)CC2=CC=CC=C2)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 467.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brennan PA, Langdon JD. A preliminary report using oxethazaine--a potential new dental local anaesthetic. Br J Oral Maxillofac Surg. 1990 Feb;28(1):26-8. PubMed PMID: 2182107.

2: Kovacs GT, Campbell J, Francis D, Hill D, Adena MA. Is mucaine an appropriate medication for the relief of heartburn during pregnancy? Asia Oceania J Obstet Gynaecol. 1990 Dec;16(4):357-62. PubMed PMID: 2099731.

3: Hsu MC, Lin SF, Kuan CP, Chu WL, Chan KH, Chang-Chien GP. Oxethazaine as the source of mephentermine and phentermine in athlete's urine. Forensic Sci Int. 2009 Mar 10;185(1-3):e1-5. doi: 10.1016/j.forsciint.2008.12.009. Epub 2009 Jan 20. PubMed PMID: 19157735.

4: Zhang L, Liu C, Xiao Y, Chen X. Oxethazaine inhibits hepatitis B virus capsid assembly by blocking the cytosolic calcium-signalling pathway. J Gen Virol. 2016 May;97(5):1198-209. doi: 10.1099/jgv.0.000417. Epub 2016 Feb 1. PubMed PMID: 26838678.

5: Masuda Y, Oguma T, Kimura A. Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells. Biochem Pharmacol. 2002 Aug 15;64(4):677-87. PubMed PMID: 12167487.

6: Huang WH, Liu CH, Liu RH, Tseng YL. Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis. J Anal Toxicol. 2010 Mar;34(2):73-7. PubMed PMID: 20223098.

7: Zanni A, Gherardi S, Crowther PS, De Tomasi F, Scott CN, Bertoli R. A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration. Curr Med Res Opin. 1986;10(2):128-34. PubMed PMID: 3519093.

8: Masuda Y, Edo T. Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers. J Pharmacol Sci. 2005 Jun;98(2):181-4. Epub 2005 Jun 8. PubMed PMID: 15942124.

9: Bhoir S, Bhagwat AM. Comparison of seven Oxethazaine containing antacids available in the Indian market. J Assoc Physicians India. 2013 Jun;61(6):400-3. PubMed PMID: 24640206.

10: HOLLANDER E. Oxethazaine for control of symptoms in refractory cases of duodenal ulcer and hiatus hernia. Am J Gastroenterol. 1960 Dec;34:613-8. PubMed PMID: 13715300.

11: Masuda Y. Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity. J Pharmacol Sci. 2006 Mar;100(3):167-74. Epub 2006 Mar 4. PubMed PMID: 16518079.

12: Anika MS. Effects of cholecystokinin and caerulein on gastric emptying. Eur J Pharmacol. 1982 Nov 19;85(2):195-9. PubMed PMID: 6897537.

13: Masuda Y, Ozaki M, Oguma T. Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver. Biochem Pharmacol. 1997 Jun 15;53(12):1779-87. PubMed PMID: 9256152.

14: Yamazaki Y. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Dig Dis Sci. 1982 Sep;27(9):821-7. PubMed PMID: 6896683.

15: GLASSMAN JM, DERVINIS A, BECKFIELD WJ, SEIFTER J. Acute and chronic toxicity of oxethazaine: a highly potent local anesthetic. Toxicol Appl Pharmacol. 1963 Mar;5:184-200. PubMed PMID: 13948386.

16: Barry MK, Aloisi JD, Yeo CJ. Neural mechanisms in basal and meal-stimulated ileal absorption. J Surg Res. 1995 Apr;58(4):425-31. PubMed PMID: 7723323.

17: JANKELSON OM, JANKELSON IR. The symptomatic, exaggerated gastrocolic reflex: its relief by an oral, topical anesthetic (oxethazaine hydrochloride). Am J Gastroenterol. 1959 Dec;32:719-22. PubMed PMID: 14406692.

18: RIDER JA, MOELLER HC, GARDEY RH. Oxethazaine hydrochloride for treatment of gastritis, peptic ulcer and esophagitis. Clin Med (Northfield). 1963 Jul;70:1271-8. PubMed PMID: 15445957.

19: BAKER JW. CLINICAL TRIAL OF ALUDROX AND OXETHAZAINE IN RADIOTHERAPY. Clin Radiol. 1963 Oct;14:442-4. PubMed PMID: 14068783.

20: Yasuno R, Oguma T, Masuda Y. Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro. Biol Pharm Bull. 1998 Dec;21(12):1294-9. PubMed PMID: 9881642. 1: Brennan PA, Langdon JD. A preliminary report using oxethazaine--a potential new dental local anaesthetic. Br J Oral Maxillofac Surg. 1990 Feb;28(1):26-8. PubMed PMID: 2182107.

2: Kovacs GT, Campbell J, Francis D, Hill D, Adena MA. Is mucaine an appropriate medication for the relief of heartburn during pregnancy? Asia Oceania J Obstet Gynaecol. 1990 Dec;16(4):357-62. PubMed PMID: 2099731.

3: Hsu MC, Lin SF, Kuan CP, Chu WL, Chan KH, Chang-Chien GP. Oxethazaine as the source of mephentermine and phentermine in athlete's urine. Forensic Sci Int. 2009 Mar 10;185(1-3):e1-5. doi: 10.1016/j.forsciint.2008.12.009. Epub 2009 Jan 20. PubMed PMID: 19157735.

4: Zhang L, Liu C, Xiao Y, Chen X. Oxethazaine inhibits hepatitis B virus capsid assembly by blocking the cytosolic calcium-signalling pathway. J Gen Virol. 2016 May;97(5):1198-209. doi: 10.1099/jgv.0.000417. Epub 2016 Feb 1. PubMed PMID: 26838678.

5: Masuda Y, Oguma T, Kimura A. Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells. Biochem Pharmacol. 2002 Aug 15;64(4):677-87. PubMed PMID: 12167487.

6: Huang WH, Liu CH, Liu RH, Tseng YL. Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis. J Anal Toxicol. 2010 Mar;34(2):73-7. PubMed PMID: 20223098.

7: Zanni A, Gherardi S, Crowther PS, De Tomasi F, Scott CN, Bertoli R. A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration. Curr Med Res Opin. 1986;10(2):128-34. PubMed PMID: 3519093.

8: Masuda Y, Edo T. Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers. J Pharmacol Sci. 2005 Jun;98(2):181-4. Epub 2005 Jun 8. PubMed PMID: 15942124.

9: Bhoir S, Bhagwat AM. Comparison of seven Oxethazaine containing antacids available in the Indian market. J Assoc Physicians India. 2013 Jun;61(6):400-3. PubMed PMID: 24640206.

10: HOLLANDER E. Oxethazaine for control of symptoms in refractory cases of duodenal ulcer and hiatus hernia. Am J Gastroenterol. 1960 Dec;34:613-8. PubMed PMID: 13715300.

11: Masuda Y. Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity. J Pharmacol Sci. 2006 Mar;100(3):167-74. Epub 2006 Mar 4. PubMed PMID: 16518079.

12: Anika MS. Effects of cholecystokinin and caerulein on gastric emptying. Eur J Pharmacol. 1982 Nov 19;85(2):195-9. PubMed PMID: 6897537.

13: Masuda Y, Ozaki M, Oguma T. Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver. Biochem Pharmacol. 1997 Jun 15;53(12):1779-87. PubMed PMID: 9256152.

14: Yamazaki Y. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Dig Dis Sci. 1982 Sep;27(9):821-7. PubMed PMID: 6896683.

15: GLASSMAN JM, DERVINIS A, BECKFIELD WJ, SEIFTER J. Acute and chronic toxicity of oxethazaine: a highly potent local anesthetic. Toxicol Appl Pharmacol. 1963 Mar;5:184-200. PubMed PMID: 13948386.

16: Barry MK, Aloisi JD, Yeo CJ. Neural mechanisms in basal and meal-stimulated ileal absorption. J Surg Res. 1995 Apr;58(4):425-31. PubMed PMID: 7723323.

17: JANKELSON OM, JANKELSON IR. The symptomatic, exaggerated gastrocolic reflex: its relief by an oral, topical anesthetic (oxethazaine hydrochloride). Am J Gastroenterol. 1959 Dec;32:719-22. PubMed PMID: 14406692.

18: RIDER JA, MOELLER HC, GARDEY RH. Oxethazaine hydrochloride for treatment of gastritis, peptic ulcer and esophagitis. Clin Med (Northfield). 1963 Jul;70:1271-8. PubMed PMID: 15445957.

19: BAKER JW. CLINICAL TRIAL OF ALUDROX AND OXETHAZAINE IN RADIOTHERAPY. Clin Radiol. 1963 Oct;14:442-4. PubMed PMID: 14068783.

20: Yasuno R, Oguma T, Masuda Y. Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro. Biol Pharm Bull. 1998 Dec;21(12):1294-9. PubMed PMID: 9881642.