WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562420
CAS#: 956958-53-5
Description: XL147-II is an ATP-competitive inhibitor of class I PI3K isoforms. It acts by abrogating Akt and S6 phosphorylation in HER2+ cells and also inducing the expression and phosphorylation of HER3 and other RTKs.
Hodoodo Cat#: H562420
Name: XL147-II
CAS#: 956958-53-5
Chemical Formula: C21H16N6O2S2
Exact Mass: 448.08
Molecular Weight: 448.510
Elemental Analysis: C, 56.24; H, 3.60; N, 18.74; O, 7.13; S, 14.30
Synonym: XL147-II; XL147 II; XL147II; XL147 derivative II; XL147derivativeII; XL147-derivative-II;
IUPAC/Chemical Name: N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methyl-benzenesulfonamide
InChi Key: MQMKRQLTIWPEDM-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H16N6O2S2/c1-13-6-9-15(10-7-13)31(28,29)27-21-20(23-16-4-2-3-5-17(16)24-21)22-14-8-11-18-19(12-14)26-30-25-18/h2-12H,1H3,(H,22,23)(H,24,27)
SMILES Code: O=S(C1=CC=C(C)C=C1)(NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 448.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Akinleye A, Avvaru P, Furqan M, Song Y, Liu D. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol. 2013 Nov 22;6(1):88. doi: 10.1186/1756-8722-6-88. Review. PubMed PMID: 24261963; PubMed Central PMCID: PMC3843585.