WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555209
CAS#: 99964-79-1
Description: Picrasidine M is a PARP-1 Inhibitor.
Hodoodo Cat#: H555209
Name: Picrasidine M
CAS#: 99964-79-1
Chemical Formula: C29H22N4O4
Exact Mass: 490.16
Molecular Weight: 490.519
Elemental Analysis: C, 71.01; H, 4.52; N, 11.42; O, 13.05
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Synonym: Picrasidine M
IUPAC/Chemical Name: 3-(2-(4,8-dimethoxy-9H-pyrido[3,4-b]indol-1-yl)ethyl)-3H-indolo[3,2,1-de][1,5]naphthyridine-5,6-dione
InChi Key: RXCDWRJHTVZARX-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H22N4O4/c1-36-23-9-5-7-18-25-24(37-2)15-30-19(27(25)31-26(18)23)11-13-32-12-10-17-16-6-3-4-8-20(16)33-28(17)21(32)14-22(34)29(33)35/h3-10,12,14-15,31H,11,13H2,1-2H3
SMILES Code: O=C1C(N2C3=C(C4=C2C=CC=C4)C=CN(CCC5=NC=C(OC)C6=C5NC7=C6C=CC=C7OC)C3=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 490.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kong L, Wang B, Yang X, Guo H, Zhang K, Zhu Z, Liu J, Hao D. Picrasidine I
from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL
Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol
Biochem. 2017;43(4):1425-1435. doi: 10.1159/000481874. Epub 2017 Oct 11. PubMed
PMID: 29017159.
2: Chen KC, Lee WY, Chen HY, Chen CY. In silico investigation of potential mTOR
inhibitors from traditional Chinese medicine for treatment of Leigh syndrome.
Biomed Res Int. 2014;2014:139492. doi: 10.1155/2014/139492. Epub 2014 Jun 23.
PubMed PMID: 25045657; PubMed Central PMCID: PMC4090453.
3: Chen KC, Sun MF, Chen CY. In Silico Investigation of Potential PARP-1
Inhibitors from Traditional Chinese Medicine. Evid Based Complement Alternat Med.
2014;2014:917605. doi: 10.1155/2014/917605. Epub 2014 Apr 30. PubMed PMID:
24876881; PubMed Central PMCID: PMC4021748.