WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527864
CAS#: 41933-33-9
Description: EcDsbB-IN-9 is a novel specific inhibitor of EcDsbB, targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.
Hodoodo Cat#: H527864
Name: EcDsbB-IN-9
CAS#: 41933-33-9
Chemical Formula: C11H8Cl2N2O
Exact Mass: 254.00
Molecular Weight: 255.098
Elemental Analysis: C, 51.79; H, 3.16; Cl, 27.79; N, 10.98; O, 6.27
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Synonym: EcDsbBIN9; EcDsbB IN 9; EcDsbB-IN-9
IUPAC/Chemical Name: 4,5-Dichloro-2-benzylpyridazin-3(2H)-one
InChi Key: AJHBQZQCDCTOFD-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H8Cl2N2O/c12-9-6-14-15(11(16)10(9)13)7-8-4-2-1-3-5-8/h1-6H,7H2
SMILES Code: O=C1C(Cl)=C(Cl)C=NN1CC2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 255.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ireland PM, McMahon RM, Marshall LE, Halili M, Furlong E, Tay S, Martin JL, Sarkar-Tyson M. Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo. Antioxid Redox Signal. 2014 Feb 1;20(4):606-17. doi: 10.1089/ars.2013.5375. Epub 2013 Sep 20. PubMed PMID: 23901809; PubMed Central PMCID: PMC3901323.
2: Shouldice SR, Heras B, Walden PM, Totsika M, Schembri MA, Martin JL. Structure and function of DsbA, a key bacterial oxidative folding catalyst. Antioxid Redox Signal. 2011 May 1;14(9):1729-60. doi: 10.1089/ars.2010.3344. Epub 2011 Jan 17. Review. PubMed PMID: 21241169.