WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555232
CAS#: 1801151-15-4
Description: BMT-108908 is a Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains. BMT-108908 displayed potent rat GluN2B binding adjunctive therapy for TRD has demonstrated a 60% response rate, with 78% of responders having maintained a response for at least 1 week.
Hodoodo Cat#: H555232
Name: BMT-108908
CAS#: 1801151-15-4
Chemical Formula: C22H25FN2O2
Exact Mass: 368.19
Molecular Weight: 368.452
Elemental Analysis: C, 71.72; H, 6.84; F, 5.16; N, 7.60; O, 8.68
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Synonym: BMT-108908; BMT 108908; BMT108908;
IUPAC/Chemical Name: (R)-1-(4-fluorobenzyl)-3-(4-(4-hydroxyphenyl)piperidin-1-yl)pyrrolidin-2-one
InChi Key: KOQYBHVHTCKDIZ-OAQYLSRUSA-N
InChi Code: InChI=1S/C22H25FN2O2/c23-19-5-1-16(2-6-19)15-25-14-11-21(22(25)27)24-12-9-18(10-13-24)17-3-7-20(26)8-4-17/h1-8,18,21,26H,9-15H2/t21-/m1/s1
SMILES Code: O=C1N(CC2=CC=C(F)C=C2)CC[C@H]1N3CCC(C4=CC=C(O)C=C4)CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 368.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Keavy D, Bristow LJ, Sivarao DV, Batchelder M, King D, Thangathirupathy S,
Macor JE, Weed MR. The qEEG Signature of Selective NMDA NR2B Negative Allosteric
Modulators; A Potential Translational Biomarker for Drug Development. PLoS One.
2016 Apr 1;11(4):e0152729. doi: 10.1371/journal.pone.0152729. eCollection 2016.
PubMed PMID: 27035340; PubMed Central PMCID: PMC4817977.
2: Weed MR, Bookbinder M, Polino J, Keavy D, Cardinal RN, Simmermacher-Mayer J,
Cometa FN, King D, Thangathirupathy S, Macor JE, Bristow LJ. Negative Allosteric
Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition
in Multiple Domains. Neuropsychopharmacology. 2016 Jan;41(2):568-77. doi:
10.1038/npp.2015.184. Epub 2015 Jun 24. PubMed PMID: 26105137; PubMed Central
PMCID: PMC5130132.
