Swerchirin

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H341307

CAS#: 521-65-3

Description: Swerchirin is a biochemical.

Chemical Structure

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Swerchirin
CAS# 521-65-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H341307
Name: Swerchirin
CAS#: 521-65-3
Chemical Formula: C15H12O6
Exact Mass: 288.06
Molecular Weight: 288.255
Elemental Analysis: C, 62.50; H, 4.20; O, 33.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Swerchirin; BRN 0313581; BRN-0313581; BRN0313581.

IUPAC/Chemical Name: Xanthen-9-one, 1,8-dihydroxy-3,5-dimethoxy-

InChi Key: GNSHHHWDGOHNPC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12O6/c1-19-7-5-9(17)12-11(6-7)21-15-10(20-2)4-3-8(16)13(15)14(12)18/h3-6,16-17H,1-2H3

SMILES Code: O=C1C2=C(OC3=C1C(O)=CC=C3OC)C=C(OC)C=C2O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 288.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Luo L, Zhao H, Luo Q. Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade. J BUON. 2018 Jan-Feb;23(1):111-116. PubMed PMID: 29552769.

2: You RR, Chen XQ, He DD, Huang CG, Jin Y, Qian SH, Ju JM, Fan JT. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(19):3764-3769. doi: 10.19540/j.cnki.cjcmm.20170807.003. Chinese. PubMed PMID: 29235293.

3: Waltenberger B, Liu R, Atanasov AG, Schwaiger S, Heiss EH, Dirsch VM, Stuppner H. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules. 2015 Nov 13;20(11):20381-90. doi: 10.3390/molecules201119703. PubMed PMID: 26580586.

4: Sarmah R. Insights from the predicted interactions of plant derived compounds to the gluco-corticoid receptor as an alternative to dexa-methasone. Bioinformation. 2012;8(20):963-9. doi: 10.6026/97320630008963. Epub 2012 Oct 13. PubMed PMID: 23275688; PubMed Central PMCID: PMC3524948.

5: Phoboo S, Pinto Mda S, Barbosa AC, Sarkar D, Bhowmik PC, Jha PK, Shetty K. Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytother Res. 2013 Feb;27(2):227-35. doi: 10.1002/ptr.4714. Epub 2012 Apr 23. PubMed PMID: 22523004.

6: Lima B, Sánchez M, Luna L, Agüero MB, Zacchino S, Filippa E, Palermo JA, Tapia A, Feresin GE. Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean Slopes of San Juan Province, Argentina. Z Naturforsch C. 2012 Jan-Feb;67(1-2):29-38. PubMed PMID: 22486039.

7: Jia J, Chen T, Wang P, Chen G, You J, Liu Y, Li Y. Preparative separation of methylswertianin, swerchirin and decussatin from the Tibetan medicinal plant Swertia mussotii using high-speed counter-current chromatography. Phytochem Anal. 2012 Jul-Aug;23(4):332-6. doi: 10.1002/pca.1362. Epub 2011 Nov 3. PubMed PMID: 22052665.

8: Shekarchi M, Hajimehdipoor H, Khanavi M, Adib N, Bozorgi M, Akbari-Adergani B. A validated method for analysis of Swerchirin in Swertia longifolia Boiss. by high performance liquid chromatography. Pharmacogn Mag. 2010 Jan;6(21):13-8. doi: 10.4103/0973-1296.59961. Epub 2010 Feb 13. PubMed PMID: 20548931; PubMed Central PMCID: PMC2881648.

9: Hajimehdipoor H, Sadeghi Z, Elmi S, Elmi A, Ghazi-Khansari M, Amanzadeh Y, Sadat-Ebrahimi SE. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. J Pharm Pharmacol. 2006 Feb;58(2):277-80. PubMed PMID: 16451758.

10: Yang H, Ding C, Duan Y, Liu J. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. J Ethnopharmacol. 2005 Apr 8;98(1-2):31-5. PubMed PMID: 15763361.

11: Hirakawa K, Yoshida M, Nagatsu A, Mizukami H, Rana V, Rawat MS, Oikawa S, Kawanishi S. Chemopreventive action of xanthone derivatives on photosensitized DNA damage. Photochem Photobiol. 2005 Mar-Apr;81(2):314-9. PubMed PMID: 15646999.

12: Kumar IV, Paul BN, Asthana R, Saxena A, Mehrotra S, Rajan G. Swertia chirayita mediated modulation of interleukin-1beta, interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha in arthritic mice. Immunopharmacol Immunotoxicol. 2003 Nov;25(4):573-83. PubMed PMID: 14686799.

13: Ya BQ, Nian LC, Li C, Gen XP. Protective effect of swerchirin on hematopoiesis in 60Co-irradiated mice. Phytomedicine. 1999 May;6(2):85-8. PubMed PMID: 10374245.

14: Saxena AM, Murthy PS, Mukherjee SK. Mode of action of three structurally different hypoglycemic agents: a comparative study. Indian J Exp Biol. 1996 Apr;34(4):351-5. PubMed PMID: 8698425.

15: Saxena AM, Bajpai MB, Murthy PS, Mukherjee SK. Mechanism of blood sugar lowering by a swerchirin-containing hexane fraction (SWI) of Swertia chirayita. Indian J Exp Biol. 1993 Feb;31(2):178-81. PubMed PMID: 8500831.

16: Saxena AM, Bajpai MB, Mukherjee SK. Swerchirin induced blood sugar lowering of streptozotocin treated hyperglycemic rats. Indian J Exp Biol. 1991 Jul;29(7):674-5. PubMed PMID: 1839020.

17: Bajpai MB, Asthana RK, Sharma NK, Chatterjee SK, Mukherjee SK. Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta Med. 1991 Apr;57(2):102-4. PubMed PMID: 1891489.

18: Agata I, Sekizaki H, Sakushima A, Nishibe S, Hisada S, Kimura K. [Studies on the constituents of medicinal plants in Hokkaido. I. On the whole herb of Swertia tetrapetala Pall. (1) (author's transl)]. Yakugaku Zasshi. 1981 Nov;101(11):1067-71. Japanese. PubMed PMID: 7343662.