WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562529
CAS#: 65236-62-6
Description: Dehydrocrenatidine is a JAK inhibitor.
Hodoodo Cat#: H562529
Name: Dehydrocrenatidine
CAS#: 65236-62-6
Chemical Formula: C15H14N2O2
Exact Mass: 254.11
Molecular Weight: 254.280
Elemental Analysis: C, 70.85; H, 5.55; N, 11.02; O, 12.58
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Synonym: Dehydrocrenatidine; TOP3; TOP-3; TOP 3;
IUPAC/Chemical Name: 1-Ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
InChi Key: LDWBTKDUAXOZRB-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14N2O2/c1-4-10-15-13(12(19-3)8-16-10)9-6-5-7-11(18-2)14(9)17-15/h4-8,17H,1H2,2-3H3
SMILES Code: COC1=CC=CC2=C1NC3=C2C(OC)=CN=C3C=C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 254.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhang J, Zhu N, Du Y, Bai Q, Chen X, Nan J, Qin X, Zhang X, Hou J, Wang Q, Yang J. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81. doi: 10.1124/mol.114.095208. Epub 2015 Jan 12. PubMed PMID: 25583084.