WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206964
CAS#: 1816294-67-3
Description: SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-4370 is reported in WO 2015153516. SR-4370 showed comparable performances to other already known LRAs, did not activate CD4+ T cells, and did not cause changes in the composition of peripheral blood mononuclear cells (PBMCs), as shown by flow cytometry analyses.
Hodoodo Cat#: H206964
Name: SR-4370
CAS#: 1816294-67-3
Chemical Formula: C17H18F2N2O
Exact Mass: 304.14
Molecular Weight: 304.341
Elemental Analysis: C, 67.09; H, 5.96; F, 12.48; N, 9.20; O, 5.26
Synonym: SR-4370; SR 4370; SR4370;
IUPAC/Chemical Name: N'-butyl-2',3'-difluoro-[1,1'-biphenyl]-4-carbohydrazide
InChi Key: OSQKWTZHYXRTBG-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
SMILES Code: O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 304.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Zutz A, Chen L, Sippl F, Humpe A, Schölz C. Epigenetic Compound Screening Uncovers Small Molecules for Reactivation of Latent HIV-1. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01815-20. doi: 10.1128/AAC.01815-20. PMID: 33139279; PMCID: PMC7927817.
