WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562564
CAS#: 381186-64-7
Description: RBC6 is an inhibitor of the binding of Ral to its effector RALBP1. It acts by inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.
Hodoodo Cat#: H562564
Name: RBC6
CAS#: 381186-64-7
Chemical Formula: C16H14Cl2N4O2
Exact Mass: 364.05
Molecular Weight: 365.210
Elemental Analysis: C, 52.62; H, 3.86; Cl, 19.41; N, 15.34; O, 8.76
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Synonym: RBC6; RBC-6; RBC 6;
IUPAC/Chemical Name: 6-Amino-4-(3,5-dichloro-2-hydroxyphenyl)-1,4-dihydro-3-propyl-pyrano[2,3-c]pyrazole-5-carbonitrile
InChi Key: NFPWWZIRTMIQKT-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14Cl2N4O2/c1-2-3-11-13-12(8-4-7(17)5-10(18)14(8)23)9(6-19)15(20)24-16(13)22-21-11/h4-5,12,23H,2-3,20H2,1H3,(H,21,22)
SMILES Code: N#CC(C1C2=CC(Cl)=CC(Cl)=C2O)=C(N)OC3=C1C(CCC)=NN3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 365.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14. PubMed PMID: 25219851; PubMed Central PMCID: PMC4351747.
2: Iwai S, Pritchard C, Mann DA, Karn J, Gait MJ. Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein. Nucleic Acids Res. 1992 Dec 25;20(24):6465-72. PubMed PMID: 1282702; PubMed Central PMCID: PMC334559.