WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407512
CAS#: 864374-00-5
Description: TP-0427736 is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. P0427736 was 300-fold higher than the inhibitory effect on ALK3. In cell-based assays, TP0427736 inhibited Smad2/3 phosphorylation in A549 cells and decreased the growth inhibition of human outer root sheath cells.
Hodoodo Cat#: H407512
Name: TP0427736
CAS#: 864374-00-5
Chemical Formula: C14H10N4S2
Exact Mass: 298.03
Molecular Weight: 298.380
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 56.36; H, 3.38; N, 18.78; S, 21.49
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Synonym: TP-0427736; TP0427736; TP0427736; TP-427736; TP427736; TP427736;
IUPAC/Chemical Name: 6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
InChi Key: LLFCXRYULHMNCG-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H10N4S2/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10/h2-7H,1H3,(H,15,16)
SMILES Code: CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)NC=N2)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 298.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Naruse T, Aoki M, Fujimoto N, Arase S, Oura H, Ueda Y, Ikeda A. Novel ALK5
inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root
sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep.
2017 Jun;69(3):485-491. doi: 10.1016/j.pharep.2017.01.024. Epub 2017 Jan 25.
PubMed PMID: 28324846.
2: Amada H, Asanuma H, Koami T, Okada A, Endo M, Ueda Y, Naruse T, Ikeda A.
Discovery of
7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
(TASP0382088): a potent and selective transforming growth factor-β type I
receptor inhibitor as a topical drug for alopecia. Chem Pharm Bull (Tokyo).
2013;61(3):286-91. PubMed PMID: 23449197.