WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562607
CAS#: 1444382-92-6
Description: BPIC is an anti-tumor agent. It acts by inhibiting inflammation and scavenging free radicals.
Hodoodo Cat#: H562607
Name: BPIC
CAS#: 1444382-92-6
Chemical Formula: C27H20N2O5
Exact Mass: 452.14
Molecular Weight: 452.460
Elemental Analysis: C, 71.67; H, 4.46; N, 6.19; O, 17.68
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: BPIC;
IUPAC/Chemical Name: Benzyl 1-[4-hydroxy-3- (methoxycarbonyl)-phenyl]-9H-pyrido[3,4-b]indole-3-carboxylate
InChi Key: QTOJFNFWYFXKQT-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H20N2O5/c1-33-26(31)20-13-17(11-12-23(20)30)24-25-19(18-9-5-6-10-21(18)28-25)14-22(29-24)27(32)34-15-16-7-3-2-4-8-16/h2-14,28,30H,15H2,1H3
SMILES Code: O=C(C1=CC2=C(C(C3=CC=C(O)C(C(OC)=O)=C3)=N1)NC4=C2C=CC=C4)OCC5=CC=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 452.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Bao J, Wang W, Yang T, Wu G. An incremental clustering method based on the boundary profile. PLoS One. 2018 Apr 20;13(4):e0196108. doi: 10.1371/journal.pone.0196108. eCollection 2018. PubMed PMID: 29677201; PubMed Central PMCID: PMC5909898.
2: Arlandis S, Franco A, Mora AM, Rebollo P. Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire. A useful tool for the diagnosis of bladder pain syndrome. Actas Urol Esp. 2018 Apr 9. pii: S0210-4806(18)30035-4. doi: 10.1016/j.acuro.2018.01.008. [Epub ahead of print] English, Spanish. PubMed PMID: 29650471.
3: Lazo F, Vivas-Ruiz DE, Sandoval GA, Rodríguez EF, Kozlova EEG, Costal-Oliveira F, Chávez-Olórtegui C, Severino R, Yarlequé A, Sanchez EF. Biochemical, biological and molecular characterization of an L-Amino acid oxidase (LAAO) purified from Bothrops pictus Peruvian snake venom. Toxicon. 2017 Dec 1;139:74-86. doi: 10.1016/j.toxicon.2017.10.001. Epub 2017 Oct 9. PubMed PMID: 29024770.
4: Chevance V, Damy T, Tacher V, Legou F, Ridouani F, Luciani A, Kobeiter H, Rahmouni A, Deux JF. Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study. Eur Radiol. 2018 Feb;28(2):816-823. doi: 10.1007/s00330-017-4984-8. Epub 2017 Aug 10. PubMed PMID: 28812126.
5: Dong H, Hwang SM, Wendland M, You L, Clarke J, Inglis B. Ultralow-field and spin-locking relaxation dispersion in postmortem pig brain. Magn Reson Med. 2017 Dec;78(6):2342-2351. doi: 10.1002/mrm.26621. Epub 2017 Feb 5. PubMed PMID: 28164366.
6: Link WA, Sauer JR. Bayesian cross-validation for model evaluation and selection, with application to the North American Breeding Bird Survey. Ecology. 2016 Jul;97(7):1746-1758. doi: 10.1890/15-1286.1. PubMed PMID: 27859161.
7: Nickel JC, Egerdie B, Davis E, Evans R, Mackenzie L, Shrewsbury SB. A Phase II Study of the Efficacy and Safety of the Novel Oral SHIP1 Activator AQX-1125 in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2016 Sep;196(3):747-54. doi: 10.1016/j.juro.2016.03.003. Epub 2016 Mar 9. PubMed PMID: 26968644.
8: Lorenzo L, Bonillo MA, Arlandis S, Martínez-Cuenca E, Marzullo L, Broseta E, Boronat F. Hydrodistension plus Onabotulinumtoxin A in bladder pain syndrome refractory to conservative treatments. Actas Urol Esp. 2016 Jun;40(5):303-8. doi: 10.1016/j.acuro.2015.12.011. Epub 2016 Feb 11. English, Spanish. PubMed PMID: 26877071.
9: Li S, Wang Y, Zhao M, Wu J, Peng S. BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1146-50. doi: 10.1016/j.bmcl.2014.12.013. Epub 2014 Dec 13. PubMed PMID: 25648297.
10: Shekaari H, Kazempour A, Khoshalhan M. Schiff base ligands and their transition metal complexes in the mixtures of ionic liquid + organic solvent: a thermodynamic study. Phys Chem Chem Phys. 2015 Jan 21;17(3):2179-91. doi: 10.1039/c4cp04432k. Epub 2014 Dec 8. PubMed PMID: 25482659.
11: Sharma S, Kim H, Lee YH, Kim T, Lee YS, Lee MH. Heteroleptic cyclometalated iridium(III) complexes supported by triarylborylpicolinate ligand: ratiometric turn-on phosphorescence response upon fluoride binding. Inorg Chem. 2014 Aug 18;53(16):8672-80. doi: 10.1021/ic501286m. Epub 2014 Aug 4. PubMed PMID: 25090619.
12: Humphrey L, Arbuckle R, Moldwin R, Nordling J, van de Merwe JP, Meunier J, Crook T, Abraham L. The bladder pain/interstitial cystitis symptom score: development, validation, and identification of a cut score. Eur Urol. 2012 Feb;61(2):271-9. doi: 10.1016/j.eururo.2011.10.004. Epub 2011 Oct 18. PubMed PMID: 22050826.
13: Riblet F, Novitchi G, Scopelliti R, Helm L, Gulea A, Merbach AE. Isomerization mechanisms of stereolabile tris- and bis-bidentate octahedral cobalt(II) complexes: X-ray structure and variable temperature and pressure NMR kinetic investigations. Inorg Chem. 2010 May 3;49(9):4194-211. doi: 10.1021/ic902494j. PubMed PMID: 20353154.
14: Oh PJ, Kim SH. Effects of a brief psychosocial intervention in patients with cancer receiving adjuvant therapy. Oncol Nurs Forum. 2010 Mar;37(2):E98-104. doi: 10.1188/10.ONF.E98-E104. PubMed PMID: 20189916.
15: Oshima S, Hirayama N, Kubono K, Kokusen H, Honjo T. Ion-pair extraction behavior of divalent metal cations using neutral di-Schiff base ligands derived from 1,2-cyclohexanediamine and o-phenylenediamine. Talanta. 2003 Apr 10;59(5):867-74. doi: 10.1016/S0039-9140(02)00651-3. PubMed PMID: 18968974.
16: Hwang IC, Ha K. Diacetato[N,N'-bis-(2-pyridylmethyl-idene)cyclo-hexane-1,2-diamine]manganese(II) hexa-hydrate. Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 6;64(Pt 3):m453. doi: 10.1107/S160053680800353X. PubMed PMID: 21201849; PubMed Central PMCID: PMC2960837.
17: Ryan MJ. The predictable swarm: staying on top of radiology's cyclical staffing "bug". Radiol Manage. 2005 May-Jun;27(3):14-20, 22-6, 28-9; quiz 30-2. PubMed PMID: 15988868.
18: Newcom DW, Baas TJ, Mabry JW, Goodwin RN. Genetic parameters for pork carcass components. J Anim Sci. 2002 Dec;80(12):3099-106. PubMed PMID: 12542149.
