FOX-7

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581217

CAS#: 145250-81-3

Description: FOX-7 or 1,1-diamino-2,2-dinitroethene (DADNE) is an insensitive high explosive compound. FOX-7 is similar to the insensitive chemical compound TATB, which is a benzene ring compound with three amino and three nitro groups. FOX-7 has a two-carbon backbone rather than a benzene ring, but the amino and nitro groups have similar effects in both cases according to published reports on sensitivity and chemical decay processes of FOX-7.


Chemical Structure

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FOX-7
CAS# 145250-81-3

Theoretical Analysis

Hodoodo Cat#: H581217
Name: FOX-7
CAS#: 145250-81-3
Chemical Formula:
Exact Mass: 0.00
Molecular Weight: 0.000
Elemental Analysis:

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: FOX-7; DADNE; ; FOX 7; FOX7; UNII-3B2KYV7C3F;

IUPAC/Chemical Name: 1,1-diamino-2,2-dinitroethylene

InChi Key: FUHQFAMVYDIUKL-UHFFFAOYSA-N

InChi Code: InChI=1S/C2H4N4O4/c3-1(4)2(5(7)8)6(9)10/h3-4H2

SMILES Code: O=[N+](/C([N+]([O-])=O)=C(N)\N)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fang X, McLuckie WG. Laser ignitibility of insensitive secondary explosive 1,1-diamino-2,2-dinitroethene (FOX-7). J Hazard Mater. 2015 Mar 21;285:375-82. doi: 10.1016/j.jhazmat.2014.12.006. Epub 2014 Dec 15. PubMed PMID: 25528237.

2: Feng RZ, Zhang SH, Ren FD, Gou RJ, Gao L. Theoretical insight into the binding energy and detonation performance of ε-, γ-, β-CL-20 cocrystals with β-HMX, FOX-7, and DMF in different molar ratios, as well as electrostatic potential. J Mol Model. 2016 Jun;22(6):123. doi: 10.1007/s00894-016-2998-9. Epub 2016 May 11. PubMed PMID: 27168198.

3: Song KP, Ren FD, Zhang SH, Shi WJ. Theoretical insights into the stabilities, detonation performance, and electrostatic potentials of cocrystals containing α- or β-HMX and TATB, FOX-7, NTO, or DMF in various molar ratios. J Mol Model. 2016 Oct;22(10):249. Epub 2016 Sep 29. PubMed PMID: 27686560.

4: Booth RS, Butler LJ. Thermal decomposition pathways for 1,1-diamino-2,2-dinitroethene (FOX-7). J Chem Phys. 2014 Oct 7;141(13):134315. doi: 10.1063/1.4896165. PubMed PMID: 25296814.

5: Di Pilato V, Arena F, Giani T, Conte V, Cresti S, Rossolini GM. Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type β-lactamase, involved in a large outbreak in a neonatal intensive care unit. J Antimicrob Chemother. 2014 Oct;69(10):2620-4. doi: 10.1093/jac/dku216. Epub 2014 Jun 13. PubMed PMID: 24928855.

6: Yuan B, Yu Z, Bernstein ER. Initial decomposition mechanism for the energy release from electronically excited energetic materials: FOX-7 (1,1-diamino-2,2-dinitroethene, C2H4N4O4). J Chem Phys. 2014 Feb 21;140(7):074708. doi: 10.1063/1.4865266. PubMed PMID: 24559361.

7: Bishop MM, Velisavljevic N, Chellappa R, Vohra YK. High Pressure-Temperature Phase Diagram of 1,1-Diamino-2,2-dinitroethylene (FOX-7). J Phys Chem A. 2015 Sep 17;119(37):9739-47. doi: 10.1021/acs.jpca.5b07811. Epub 2015 Sep 8. PubMed PMID: 26317366.

8: Vo TT, Parrish DA, Shreeve JM. 1,1-Diamino-2,2-dintroethene (FOX-7) in copper and nickel diamine complexes and copper FOX-7. Inorg Chem. 2012 Feb 6;51(3):1963-8. doi: 10.1021/ic202288t. Epub 2012 Jan 6. PubMed PMID: 22224456.

9: Gao H, Shreeve JM. The Many Faces of FOX-7: A Precursor to High-Performance Energetic Materials. Angew Chem Int Ed Engl. 2015 May 18;54(21):6335-8. doi: 10.1002/anie.201501973. Epub 2015 Mar 30. PubMed PMID: 25827119.

10: Larentzos JP, Rice BM, Byrd EF, Weingarten NS, Lill JV. Parameterizing complex reactive force fields using multiple objective evolutionary strategies (MOES). Part 1: ReaxFF models for cyclotrimethylene trinitramine (RDX) and 1,1-diamino-2,2-dinitroethene (FOX-7). J Chem Theory Comput. 2015 Feb 10;11(2):381-91. doi: 10.1021/ct500788c. PubMed PMID: 26580902.

11: Srinivas D, Mitchell LA, Parrish DA, Shreeve JM. From FOX-7 to H-FOX to insensitive energetic materials with hypergolic properties. Chem Commun (Camb). 2016 Jun 8;52(49):7668-71. doi: 10.1039/c6cc02669a. PubMed PMID: 27225382.

12: Dharavath S, Mitchell LA, Parrish DA, Shreeve JM. Correction: From FOX-7 to H-FOX to insensitive energetic materials with hypergolic properties. Chem Commun (Camb). 2016 Jun 21;52(52):8168. PubMed PMID: 27278594.

13: Žabka J, Šimková L, Jalový Z, Polášek M. The unimolecular chemistry of protonated and deprotonated 2,2-dinitroethene-1,1-diamine (FOX-7) studied by tandem mass spectrometry and computational chemistry. Eur J Mass Spectrom (Chichester). 2014;20(3):233-47. doi: 10.1255/ejms.1273. PubMed PMID: 24892294.

14: Borges I Jr. Electronic and ionization spectra of 1,1-diamino-2,2-dinitroethylene, FOX-7. J Mol Model. 2014 Mar;20(3):2095. doi: 10.1007/s00894-014-2095-x. Epub 2014 Feb 18. PubMed PMID: 24535107.

15: Kiselev VG, Gritsan NP. Unexpected primary reactions for thermolysis of 1,1-diamino-2,2-dinitroethylene (FOX-7) revealed by ab initio calculations. J Phys Chem A. 2014 Sep 11;118(36):8002-8. doi: 10.1021/jp507102x. Epub 2014 Aug 20. PubMed PMID: 25141156.

16: Vo TT, Zhang J, Parrish DA, Twamley B, Shreeve JM. New roles for 1,1-diamino-2,2-dinitroethene (FOX-7): halogenated FOX-7 and azo-bis(diahaloFOX) as energetic materials and oxidizers. J Am Chem Soc. 2013 Aug 14;135(32):11787-90. doi: 10.1021/ja406629g. Epub 2013 Aug 6. PubMed PMID: 23909984.

17: Averkiev BB, Dreger ZA, Chaudhuri S. Density functional theory calculations of pressure effects on the structure and vibrations of 1,1-diamino-2,2-dinitroethene (FOX-7). J Phys Chem A. 2014 Oct 30;118(43):10002-10. doi: 10.1021/jp508869n. Epub 2014 Oct 21. PubMed PMID: 25289985.

18: Arena F, Giani T, Becucci E, Conte V, Zanelli G, D'Andrea MM, Buonocore G, Bagnoli F, Zanchi A, Montagnani F, Rossolini GM. Large oligoclonal outbreak due to Klebsiella pneumoniae ST14 and ST26 producing the FOX-7 AmpC β-lactamase in a neonatal intensive care unit. J Clin Microbiol. 2013 Dec;51(12):4067-72. doi: 10.1128/JCM.01982-13. Epub 2013 Oct 2. PubMed PMID: 24088849; PubMed Central PMCID: PMC3838045.

19: He P, Zhang JG, Wang K, Yin X, Jin X, Zhang TL. Extensive theoretical studies on two new members of the FOX-7 family: 5-(dinitromethylene)-1,4-dinitramino-tetrazole and 1,1'-dinitro-4,4'-diamino-5,5'-bitetrazole as energetic compounds. Phys Chem Chem Phys. 2015 Feb 28;17(8):5840-8. doi: 10.1039/c4cp04883k. PubMed PMID: 25631492.

20: Civis M, Civis S, Sovová K, Dryahina K, Spanel P, Kyncl M. Laser ablation of FOX-7: proposed mechanism of decomposition. Anal Chem. 2011 Feb 1;83(3):1069-77. doi: 10.1021/ac1028769. Epub 2011 Jan 12. PubMed PMID: 21226460.