WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H341541
CAS#: 535-89-7
Description: Crimidine is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was originally produced in the 1940s by the conglomerate, IG Farben.
Hodoodo Cat#: H341541
Name: Crimidine
CAS#: 535-89-7
Chemical Formula: C7H10ClN3
Exact Mass: 171.06
Molecular Weight: 171.628
Elemental Analysis: C, 48.99; H, 5.87; Cl, 20.66; N, 24.48
Synonym: Crimidine; W-491; W-491; W-491; NSC 2017; NSC-2017; NSC2017.
IUPAC/Chemical Name: 2-Chloro-4-dimethylamino-6-methylpyrimidine
InChi Key: HJIUPFPIEBPYIE-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H10ClN3/c1-5-4-6(11(2)3)10-7(8)9-5/h4H,1-3H3
SMILES Code: CC1=CC(N(C)C)=NC(Cl)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 171.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lumeij JT, Schotman AJ, de Vries HW. Crimidine (2-chloro-4-(dimethylamino)-6-methylpyrimidine) poisoning in a dog due to ingestion of the rodenticide Castrix. Vet Q. 1983 Jul;5(3):107-11. doi: 10.1080/01652176.1983.9693882. PMID: 6636500.
2: De Saqui-Sannes P, Nups P, Le Bars P, Burgat V. Evaluation of an HPTLC method for the determination of strychnine and crimidine in biological samples. J Anal Toxicol. 1996 May-Jun;20(3):185-8. doi: 10.1093/jat/20.3.185. PMID: 8735200.
3: Besnard T, Sadeg N, Ricart N, Richecoeur J, Nisse P, Vinner E, Houdret N, Humbert L, Ihermitte M. Détermination sérique de la crimidine par CLHP/ES/SM chez un patient ayant ingere un "souricide foudroyant" [Serial determination of crimidine by HPLC/SE/SM in a patient ingesting a "mouse trap"]. Acta Clin Belg. 2002;57 Suppl 1:8-11. French. PMID: 11974448.
4: Besnard T, Sadeg N, Ricart N, Richecœur J, Nisse P, Vinner E, Houdret N, Humbert L, Lhermitte M. Determination serique de la crimidine par clhp/es/sm chez un patient ayant ingere un « souricide foudroyant ». Acta Clin Belg. 2002;57 Suppl 1:8-11. doi: 10.1179/acb.2002.069. PMID: 24862517.
5: Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. Eur J Emerg Med. 2005 Apr;12(2):78-85. doi: 10.1097/00063110-200504000-00007. PMID: 15756083.
6: N'dohou EHN, Gervais N'K, Paul GU, Marius KT, Marcellin YK, Paul KE. Spatial and seasonal distribution of pesticides in the waters of Azagny area (Grand Lahou, Cote d'Ivoire). Environ Monit Assess. 2023 Apr 29;195(5):626. doi: 10.1007/s10661-023-11179-9. PMID: 37119335.
7: Zimmermann R, Steinberg TA, Raith K, Hülsmeyer V, Fischer A. Canine status epilepticus due to acute intoxication. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2010;38(5):285-94. PMID: 22215313.
8: Yamashita Y. Action site of antagonists of vitamin B6 in the central nervous system of the frogs and cockroaches. J Nutr Sci Vitaminol (Tokyo). 1975;21(3):163-7. doi: 10.3177/jnsv.21.163. PMID: 1206440.
9: KNUDSEN E. THE TOXICITY OF THE RODENTICIDE CASTRIX (2-CHLORO-4-DIAMETHYLAMINO-6-METHYLPYRIMIDINE) AND THE ANTIDOTAL EFFECT OF VITAMIN B6. Acta Pharmacol Toxicol (Copenh). 1963;20:295-302. doi: 10.1111/j.1600-0773.1964.tb01749.x. PMID: 14162811.
10: KARLOG O, KNUDSEN E. VITAMIN B6 AS AN ANTIDOTE AGAINST THE RODENTICIDE 'CASTRIX' (2-CHLORO-4-METHYL-6-DIMETHYLAMINOPYRIMIDIN). Nature. 1963 Nov 23;200:790. doi: 10.1038/200790a0. PMID: 14087021.
11: DUBOIS KP, COCHRAN KW, THOMSON JF. Rodenticidal action of 2-chloro-4-dimethylamino-6-methylpyrimidine (castrix). Proc Soc Exp Biol Med. 1948 Feb;67(2):169-71. doi: 10.3181/00379727-67-16238p. PMID: 18907617.
12: Murakami Y, Matsuda M. The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain. Biochem Pharmacol. 1976 Mar 15;25(6):639-42. doi: 10.1016/0006-2952(76)90237-9. PMID: 1275947.
13: CRAMPTON JM, VOSS E. An investigation of the chronic toxicity and acceptability of Castrix. J Am Pharm Assoc Am Pharm Assoc. 1952 Mar;41(3):135-8. doi: 10.1002/jps.3030410308. PMID: 14927481.
14: Sun ZQ. [Single dose of 2 acute rodenticides used in a village]. Zhonghua Liu Xing Bing Xue Za Zhi. 1985 Oct;6(5):296-9. Chinese. PMID: 3836748.
15: GOLDBACH H. Ueber eine tödliche Vergiftung mit dem Rattenvertilgungsmittel "Castrix" [Fatal poisoning with castrix (hydrochloride of 2-chlor-4-methyl-6-dimethylaminopyrimidine), a rat poison]. Med Klin. 1950 Aug 4;45(31):961-3. Undetermined Language. PMID: 15438607.
