Microfarin

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H571564

CAS#: 101468-14-8

Description: Microfarin is a biochemical.


Chemical Structure

img
Microfarin
CAS# 101468-14-8

Theoretical Analysis

Hodoodo Cat#: H571564
Name: Microfarin
CAS#: 101468-14-8
Chemical Formula: C19H16O4
Exact Mass: 308.10
Molecular Weight: 308.330
Elemental Analysis: C, 74.01; H, 5.23; O, 20.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Acid (enol) warfarin; Microcrystalline warfarin; Microfarin

IUPAC/Chemical Name: Coumarin, 4-hydroxy-3-(alpha-(2-hydroxyallyl)benzyl)-

InChi Key: BBOSKMPTDUUMKL-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,20-21H,1,11H2

SMILES Code: O=C1OC2=C(C=CC=C2)C(O)=C1C(CC(O)=C)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 308.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhu JJ, Jiang JG. Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships. Mol Nutr Food Res. 2018 May 11:e1701073. doi: 10.1002/mnfr.201701073. [Epub ahead of print] Review. PubMed PMID: 29750855.

2: Bhavya P, Melavanki R, Kusanur R, Sharma K, Muttannavar VT, Naik LR. Effect of viscosity and dielectric constant variation on fractional fluorescence quenching analysis of coumarin dye in binary solvent mixtures. Luminescence. 2018 May 10. doi: 10.1002/bio.3492. [Epub ahead of print] PubMed PMID: 29745063.

3: Shu X, Zheng W, Yu D, Lan Li H, Lan Q, Yang G, Cai H, Ma X, Rothman N, Gao YT, Jia W, Xiang YB, Shu XO. Prospective metabolomics study identifies potential novel blood metabolites associated with pancreatic cancer risk. Int J Cancer. 2018 May 1. doi: 10.1002/ijc.31574. [Epub ahead of print] PubMed PMID: 29717485.

4: Li ZY, Su HK, Tong HX, Yin Y, Xiao T, Sun XQ, Jiang J, Wang L. Calix[4]arene containing thiourea and coumarin functionality as highly selective fluorescent and colorimetric chemosensor for fluoride ion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jul 5;200:307-312. doi: 10.1016/j.saa.2018.04.040. Epub 2018 Apr 21. PubMed PMID: 29704730.

5: Rudnitzki F, Feineis S, Rahmanzadeh R, Endl E, Groll J, Hüttmann G. siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase. J Biophotonics. 2018 Apr 27:e201700329. doi: 10.1002/jbio.201700329. [Epub ahead of print] PubMed PMID: 29704320.

6: Chaichamnong N, Temkitthawon P, Khorana N, Pitpakdeeanan P, Taepavarapruk P, Nuengchamnong N, Siriwattanasathien Y, Suksamrarn A, Ingkaninan K. Phosphodiesterase 5 Inhibitors from Derris scandens. Planta Med. 2018 Apr 27. doi: 10.1055/a-0619-5547. [Epub ahead of print] PubMed PMID: 29702722.

7: Kalaiarasi G, Rex Jeya Rajkumar S, Aswini G, Dharani S, Fronczek FR, Prabhakaran R. 3-Acetyl-8-methoxy-2[H]-chromen-2-one derived Schiff bases as potent antiproliferative agents: Insight into the influence of 4(N)-substituents on the in vitro biological activity. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jul 5;200:246-262. doi: 10.1016/j.saa.2018.04.028. Epub 2018 Apr 14. PubMed PMID: 29694929.

8: Feng S, He X, Zhong P, Zhao J, Huang C, Hu Z. A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats. Molecules. 2018 Apr 25;23(5). pii: E1004. doi: 10.3390/molecules23051004. PubMed PMID: 29693578.

9: Kushwah V, Katiyar SS, Agrawal AK, Gupta RC, Jain S. Co-delivery of docetaxel and gemcitabine using PEGylated self-assembled stealth nanoparticles for improved breast cancer therapy. Nanomedicine. 2018 Apr 20. pii: S1549-9634(18)30081-9. doi: 10.1016/j.nano.2018.04.009. [Epub ahead of print] PubMed PMID: 29684527.

10: Qin HY, Zhao WX, Zhao W, Zhang C, Feng XQ, Liu SP, Wang KG. Parametric investigations on the saturation intensity of Coumarin 102 for stimulated emission depletion application. J Microsc. 2018 Apr 23. doi: 10.1111/jmi.12703. [Epub ahead of print] PubMed PMID: 29683482.

11: Deng Z, Jiao MJ, Zhang J, Shen L, Wang SH, Zhang GY, Zhang Q, Liu A, Wang YS. [Research on quality standard of processed Cinnamomi Cortex decoction pieces containing volatile oil]. Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(5):885-890. doi: 10.19540/j.cnki.cjcmm.20180108.001. Chinese. PubMed PMID: 29676083.

12: Arafat B, Qinna N, Cieszynska M, Forbes RT, Alhnan MA. Tailored on demand anti-coagulant dosing: an in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms. Eur J Pharm Biopharm. 2018 Apr 16. pii: S0939-6411(17)31106-2. doi: 10.1016/j.ejpb.2018.04.010. [Epub ahead of print] PubMed PMID: 29673871.

13: Kumar S, Saini V, Maurya IK, Sindhu J, Kumari M, Kataria R, Kumar V. Design, synthesis, DFT, docking studies and ADME prediction of some new coumarinyl linked pyrazolylthiazoles: Potential standalone or adjuvant antimicrobial agents. PLoS One. 2018 Apr 19;13(4):e0196016. doi: 10.1371/journal.pone.0196016. eCollection 2018. PubMed PMID: 29672633; PubMed Central PMCID: PMC5908142.

14: Feng WY, Wen J, Stauber K. In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS. Drug Metab Lett. 2018 Apr 18. doi: 10.2174/1872312812666180418142056. [Epub ahead of print] PubMed PMID: 29669508.

15: Moncada-Basualto M, Lapier M, Maya JD, Matsuhiro B, Olea-Azar C, Delogu GL, Uriarte E, Santana L, Matose MJ. Evaluation of trypanocidal and antioxidant activities of a selected series of 3-amidocoumarins. Med Chem. 2018 Apr 18. doi: 10.2174/1573406414666180419113437. [Epub ahead of print] PubMed PMID: 29669503.

16: Mishra R, Jana A, Panday AK, Choudhury LH. Synthesis of fused pyrroles containing 4-hydroxycoumarins by regioselective metal-free multicomponent reactions. Org Biomol Chem. 2018 May 2;16(17):3289-3302. doi: 10.1039/c8ob00161h. PubMed PMID: 29667668.

17: Baruah P, Basumatary G, Yesylevskyy SO, Aguan K, Bez G, Mitra S. Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. J Biomol Struct Dyn. 2018 May 7:1-16. doi: 10.1080/07391102.2018.1465853. [Epub ahead of print] PubMed PMID: 29663860.

18: Kumari S, Shakoor SMA, Khullar S, Mandal SK, Sakhuja R. An unprecedented tandem synthesis of fluorescent coumarin-fused pyrimidines via copper-catalyzed cross-dehydrogenative C(sp(3))-N bond coupling. Org Biomol Chem. 2018 May 2;16(17):3220-3228. doi: 10.1039/c8ob00586a. PubMed PMID: 29662999.

19: Peng S, Zhao Y, Fu C, Pu X, Zhou L, Huang Y, Lu Z. Acquiring High-Performance Deep-Blue OLED Emitters through an Unexpected Blueshift Color-Tuning Effect Induced by Electron-Donating -OMe Substituents. Chemistry. 2018 Apr 14. doi: 10.1002/chem.201800974. [Epub ahead of print] PubMed PMID: 29655182.

20: Tang B, Zaro JL, Shen Y, Chen Q, Yu Y, Sun P, Wang Y, Shen WC, Tu J, Sun C. Acid-sensitive hybrid polymeric micelles containing a reversibly activatable cell-penetrating peptide for tumor-specific cytoplasm targeting. J Control Release. 2018 Apr 10;279:147-156. doi: 10.1016/j.jconrel.2018.04.016. [Epub ahead of print] PubMed PMID: 29653223.