SR-3576
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562693

CAS#: 1164153-22-3

Description: SR-3576 is a potent JNK3 inhibitor that is highly selective over p38.

Chemical Structure

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SR-3576
CAS# 1164153-22-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H562693
Name: SR-3576
CAS#: 1164153-22-3
Chemical Formula: C27H27N5O5
Exact Mass: 501.20
Molecular Weight: 501.540
Elemental Analysis: C, 64.66; H, 5.43; N, 13.96; O, 15.95

Price and Availability

Size Price Availability Quantity
1mg USD 150 2 Weeks
5mg USD 400 2 Weeks
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Synonym: SR-3576; SR 3576; SR3576;

IUPAC/Chemical Name: 3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide

InChi Key: MTFAYLZZDJGFGV-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)

SMILES Code: O=C(NC1=CC(OC)=C(OC)C(OC)=C1)C2=CC=CC(N3N=CC(NC(NC4=CC=CC(C)=C4)=O)=C3)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 501.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. PubMed PMID: 19261605; PubMed Central PMCID: PMC2676016.