WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596037
CAS#: 685885-75-0
Description: E-2508 free base is a bioactive chemical.
Hodoodo Cat#: H596037
Name: E-2508 free base
CAS#: 685885-75-0
Chemical Formula: C29H39N3O4
Exact Mass: 493.29
Molecular Weight: 493.640
Elemental Analysis: C, 70.56; H, 7.96; N, 8.51; O, 12.96
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: E-2508 free base; J2.971.745A;
IUPAC/Chemical Name: N-(cyclopropylmethyl)-7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-ethyl-N-((tetrahydro-2H-pyran-4-yl)methyl)pyrazolo[1,5-a]pyridin-3-amine
InChi Key: KGMOFBPANMLEMS-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H39N3O4/c1-5-23-29(31(17-20-9-10-20)18-21-11-13-36-14-12-21)25-8-6-7-24(32(25)30-23)28-26(34-3)15-22(19-33-2)16-27(28)35-4/h6-8,15-16,20-21H,5,9-14,17-19H2,1-4H3
SMILES Code: CCC1=NN2C(C3=C(OC)C=C(COC)C=C3OC)=CC=CC2=C1N(CC4CC4)CC5CCOCC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 493.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Olabi M, Stein M, Wätzig H. Affinity capillary electrophoresis for studying interactions in life sciences. Methods. 2018 May 10. pii: S1046-2023(17)30425-5. doi: 10.1016/j.ymeth.2018.05.006. [Epub ahead of print] Review. PubMed PMID: 29753786.
2: Potysz A, van Hullebusch ED, Kierczak J. Perspectives regarding the use of metallurgical slags as secondary metal resources - A review of bioleaching approaches. J Environ Manage. 2018 May 5;219:138-152. doi: 10.1016/j.jenvman.2018.04.083. [Epub ahead of print] Review. PubMed PMID: 29738933.
3: Lim D, Ma BC, Parumo R, Shanmuhasuntharam P. Thirty years of submental intubation: a review. Int J Oral Maxillofac Surg. 2018 May 3. pii: S0901-5027(18)30146-2. doi: 10.1016/j.ijom.2018.04.015. [Epub ahead of print] Review. PubMed PMID: 29731193.
4: Seebregts C, Dane P, Parsons AN, Fogwill T, Rogers D, Bekker M, Shaw V, Barron P. Designing for scale: optimising the health information system architecture for mobile maternal health messaging in South Africa (MomConnect). BMJ Glob Health. 2018 Apr 24;3(Suppl 2):e000563. doi: 10.1136/bmjgh-2017-000563. eCollection 2018. Review. PubMed PMID: 29713506; PubMed Central PMCID: PMC5922467.
5: Khawaja AM, Venkatraman A, Mirza M. Clival Chordoma: Case Report and Review of Recent Developments in Surgical and Adjuvant Treatments. Pol J Radiol. 2017 Nov 17;82:670-675. doi: 10.12659/PJR.902008. eCollection 2017. Review. PubMed PMID: 29662593; PubMed Central PMCID: PMC5894024.
6: Sosson M, Richert C. Enzyme-free genetic copying of DNA and RNA sequences. Beilstein J Org Chem. 2018 Mar 12;14:603-617. doi: 10.3762/bjoc.14.47. eCollection 2018. Review. PubMed PMID: 29623122; PubMed Central PMCID: PMC5870163.
7: Lohman TM, Fazio NT. How Does a Helicase Unwind DNA? Insights from RecBCD Helicase. Bioessays. 2018 Mar 30. doi: 10.1002/bies.201800009. [Epub ahead of print] Review. PubMed PMID: 29603305.
8: Price L, Melone L, McLarnon N, Bunyan D, Kilpatrick C, Flowers P, Reilly J. A systematic review to evaluate the evidence base for the World Health Organization's adopted hand hygiene technique for reducing the microbial load on the hands of healthcare workers. Am J Infect Control. 2018 Mar 27. pii: S0196-6553(18)30065-8. doi: 10.1016/j.ajic.2018.01.020. [Epub ahead of print] Review. PubMed PMID: 29602496.
9: Stainthorpe A, Greenhalgh J, Bagust A, Richardson M, Boland A, Beale S, Duarte R, Kotas E, Banks L, Palmer D. Paclitaxel as Albumin-Bound Nanoparticles with Gemcitabine for Untreated Metastatic Pancreatic Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. 2018 Mar 29. doi: 10.1007/s40273-018-0646-1. [Epub ahead of print] Review. PubMed PMID: 29600384.
10: Trajano LADSN, Trajano ETL, Silva MADS, Stumbo AC, Mencalha AL, Fonseca ASD. Genomic stability and telomere regulation in skeletal muscle tissue. Biomed Pharmacother. 2018 Feb;98:907-915. doi: 10.1016/j.biopha.2018.01.004. Epub 2018 Jan 8. Review. PubMed PMID: 29571261.
11: Tsikas D, Schwedhelm KS, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S. S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)-Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H(2)S and GSH suppliers and as antioxidants: Results and overview. J Pharm Anal. 2018 Feb;8(1):1-9. doi: 10.1016/j.jpha.2017.12.003. Epub 2017 Dec 13. Review. PubMed PMID: 29568662; PubMed Central PMCID: PMC5859134.
12: Levenson JS. Sex Offender Management Policies and Evidence-Based Recommendations for Registry Reform. Curr Psychiatry Rep. 2018 Mar 21;20(3):21. doi: 10.1007/s11920-018-0884-0. Review. PubMed PMID: 29560559.
13: Ahmed I, Ahmad NS, Ali S, Ali S, George A, Saleem Danish H, Uppal E, Soo J, Mobasheri MH, King D, Cox B, Darzi A. Medication Adherence Apps: Review and Content Analysis. JMIR Mhealth Uhealth. 2018 Mar 16;6(3):e62. doi: 10.2196/mhealth.6432. Review. PubMed PMID: 29549075; PubMed Central PMCID: PMC5878368.
14: Motsumi MJ, Motlaleselelo P, Ayane G, Sesay SO, Valdes JR. A case report of a giant appendiceal mucocele and literature review. Pan Afr Med J. 2017 Oct 4;28:106. doi: 10.11604/pamj.2017.28.106.13832. eCollection 2017. Review. PubMed PMID: 29515724; PubMed Central PMCID: PMC5837178.
15: Trajano LADSN, Sergio LPDS, Stumbo AC, Mencalha AL, Fonseca ASD. Low power lasers on genomic stability. J Photochem Photobiol B. 2018 Mar;180:186-197. doi: 10.1016/j.jphotobiol.2018.02.010. Epub 2018 Feb 10. Review. PubMed PMID: 29454225.
16: Dowd KP, Szeklicki R, Minetto MA, Murphy MH, Polito A, Ghigo E, van der Ploeg H, Ekelund U, Maciaszek J, Stemplewski R, Tomczak M, Donnelly AE. A systematic literature review of reviews on techniques for physical activity measurement in adults: a DEDIPAC study. Int J Behav Nutr Phys Act. 2018 Feb 8;15(1):15. doi: 10.1186/s12966-017-0636-2. Review. PubMed PMID: 29422051; PubMed Central PMCID: PMC5806271.
17: Duek I, Pener-Tessler A, Yanko-Arzi R, Zaretski A, Abergel A, Safadi A, Fliss DM. Skull Base Reconstruction in the Pediatric Patient. J Neurol Surg B Skull Base. 2018 Feb;79(1):81-90. doi: 10.1055/s-0037-1615806. Epub 2018 Jan 5. Review. PubMed PMID: 29404244; PubMed Central PMCID: PMC5796825.
18: Venkataramanan V, Crocker J, Karon A, Bartram J. Community-Led Total Sanitation: A Mixed-Methods Systematic Review of Evidence and Its Quality. Environ Health Perspect. 2018 Feb 2;126(2):026001. doi: 10.1289/EHP1965. Review. PubMed PMID: 29398655.
19: Wu G, Liang Q, Liu Y. Primary osteosarcoma of frontal bone: A case report and review of literature. Medicine (Baltimore). 2017 Dec;96(51):e9392. doi: 10.1097/MD.0000000000009392. Review. PubMed PMID: 29390546; PubMed Central PMCID: PMC5758248.
20: Khwairakpam AD, Damayenti YD, Deka A, Monisha J, Roy NK, Padmavathi G, Kunnumakkara AB. Acorus calamus: a bio-reserve of medicinal values. J Basic Clin Physiol Pharmacol. 2018 Mar 28;29(2):107-122. doi: 10.1515/jbcpp-2016-0132. Review. PubMed PMID: 29389665.