WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562735
CAS#: 125741-64-2
Description: S-Fcme is a multidrug resistance transporter activator. It acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding.
Hodoodo Cat#: H562735
Name: S-Fcme
CAS#: 125741-64-2
Chemical Formula: C19H33NO2S
Exact Mass: 339.22
Molecular Weight: 339.538
Elemental Analysis: C, 67.21; H, 9.80; N, 4.13; O, 9.42; S, 9.44
Synonym: S-Fcme; SFcme; S Fcme;
IUPAC/Chemical Name: S-Farnesyl-L-cysteine Methyl Ester
InChi Key: SIEHZFPZQUNSAS-GCVUPTOQSA-N
InChi Code: InChI=1S/C19H33NO2S/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-23-14-18(20)19(21)22-5/h8,10,12,18H,6-7,9,11,13-14,20H2,1-5H3/b16-10+,17-12+/t18-/m0/s1
SMILES Code: N[C@@H](CSC/C=C(CC/C=C(CC/C=C(C)/C)\C)\C)C(OC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 339.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Oboh OT, Lamango NS. Liver prenylated methylated protein methyl esterase is the same enzyme as Sus scrofa carboxylesterase. J Biochem Mol Toxicol. 2008 Feb;22(1):51-62. doi: 10.1002/jbt.20214. PubMed PMID: 18273909; PubMed Central PMCID: PMC3766356.
2: Park SB, Howald WN, Cashman JR. S-oxidative cleavage of farnesylcysteine and farnesylcysteine methyl ester by the flavin-containing monooxygenase. Chem Res Toxicol. 1994 Mar-Apr;7(2):191-8. PubMed PMID: 8199308.
3: Stimmel JB, Deschenes RJ, Volker C, Stock J, Clarke S. Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein. Biochemistry. 1990 Oct 16;29(41):9651-9. PubMed PMID: 2271607.