WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562737
CAS#: 543-21-5
Description: Cellocidin is a potent growth inhibitor for gammaherpesvirus-associated B-lymphomas that acts through activation of both the NF-κB and c-Myc-mediated signaling pathways.
Hodoodo Cat#: H562737
Name: Cellocidin
CAS#: 543-21-5
Chemical Formula: C4H4N2O2
Exact Mass: 112.03
Molecular Weight: 112.080
Elemental Analysis: C, 42.86; H, 3.60; N, 24.99; O, 28.55
Synonym: NSC-65381; NSC65381; NSC 65381; Cellocidin; NSC#65381; NSC# 65381; NSC#-65381; Lenamycin; Aquamycin; Acetylene dicarboxamide;
IUPAC/Chemical Name: But-2-ynediamide
InChi Key: JBTGHKUTYAMZEZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C4H4N2O2/c5-3(7)1-2-4(6)8/h(H2,5,7)(H2,6,8)
SMILES Code: O=C(N)C#CC(N)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 112.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: SUZUKI S, NAKAMURA G, OKUMA K, TOMIYAMA Y. Cellocidin, a new antibiotic. J Antibiot (Tokyo). 1958 May;11(3):81-3. PMID: 13563326.
2: SUZUKI S, OKUMA K. The structure of cellocidin. J Antibiot (Tokyo). 1958 May;11(3):84-6. PMID: 13563327.
3: Jakhmola S, Hazarika Z, Jha AN, Jha HC. In silico analysis of antiviral phytochemicals efficacy against Epstein-Barr virus glycoprotein H. J Biomol Struct Dyn. 2022 Aug;40(12):5372-5385. doi: 10.1080/07391102.2020.1871074. Epub 2021 Jan 13. PMID: 33438528.
4: Yoneyama K, Sekido S, Misato T. Antagonistic mechanism of sulfhydryl compounds on cellocidin activity. J Antibiot (Tokyo). 1978 Oct;31(10):1065-6. doi: 10.7164/antibiotics.31.1065. PMID: 711614.
5: Otoguro K, Ishiyama A, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Yamada H, Omura S. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J Antibiot (Tokyo). 2008 Jun;61(6):372-8. doi: 10.1038/ja.2008.52. PMID: 18667785.
6: Jones ER, Keeping JW, Pellatt MG, Thaller V. Natural acetylenes. 38. Biosyntheses of acetylenedicarboxamide (cellocidin) in Streptomyces SF-536 cultures. J Chem Soc Perkin 1. 1973;2:148-50. doi: 10.1039/p19730000148. PMID: 4736298.
