Diuron
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581239

CAS#: 330-54-1

Description: Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH.1 It decreases total respiration in roots of wheat by 50% and ground respiration by 100% when used at a concentration of 25 nM/ml.2 Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.1 It increases the production of reactive oxygen species (ROS) in MCF-7 human breast adenocarcinoma and BeWo human placental choriocarcinoma cells when used at a concentration of 200 µM and reduces viability of BeWo, but not MCF-7, cells when used at concentrations of 50 and 200 µM.3 Formulations containing diuron have been used to control broadleaf and grass weeds and as a biocidal antifouling agent.

Chemical Structure

img
Diuron
CAS# 330-54-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H581239
Name: Diuron
CAS#: 330-54-1
Chemical Formula: C9H10Cl2N2O
Exact Mass: 232.02
Molecular Weight: 233.092
Elemental Analysis: C, 46.38; H, 4.32; Cl, 30.42; N, 12.02; O, 6.86

Price and Availability

Size Price Availability Quantity
5g USD 250 2 weeks
25g USD 450 2 weeks
Bulk inquiry

Synonym: Diuron; Dirurol; HW 920; Karmex; Lucenit; Marmer; Seduron; Daion;

IUPAC/Chemical Name: 1,1-Dimethyl-3-(3,4-dichlorophenyl)urea

InChi Key: XMTQQYYKAHVGBJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H10Cl2N2O/c1-13(2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)C

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 233.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Huovinen M, Loikkanen J, Naarala J, Vähäkangas K. Toxicity of diuron in human cancer cells. Toxicol In Vitro. 2015 Oct;29(7):1577-86. doi: 10.1016/j.tiv.2015.06.013. Epub 2015 Jun 15. PubMed PMID: 26086120.

2: Durmuş N, Bekircan T. Pretreatment with polyamines alleviate the deleterious effects of diuron in maize leaves. Acta Biol Hung. 2015 Mar;66(1):52-65. doi: 10.1556/ABiol.66.2015.1.5. PubMed PMID: 25740438.

3: Moisset S, Kim Tiam S, Feurtet-Mazel A, Morin S, Delmas F, Mazzella N, Gonzalez P. Genetic and physiological responses of three freshwater diatoms to realistic diuron exposures. Environ Sci Pollut Res Int. 2015 Mar;22(6):4046-55. doi: 10.1007/s11356-014-3523-2. Epub 2014 Sep 16. PubMed PMID: 25223354.

4: Kaonga CC, Takeda K, Sakugawa H. Diuron, Irgarol 1051 and Fenitrothion contamination for a river passing through an agricultural and urban area in Higashi Hiroshima City, Japan. Sci Total Environ. 2015 Jun 15;518-519:450-8. doi: 10.1016/j.scitotenv.2015.03.022. Epub 2015 Mar 13. PubMed PMID: 25777951.

5: Negri AP, Flores F, Mercurio P, Mueller JF, Collier CJ. Lethal and sub-lethal chronic effects of the herbicide diuron on seagrass. Aquat Toxicol. 2015 Aug;165:73-83. doi: 10.1016/j.aquatox.2015.05.007. Epub 2015 May 14. PubMed PMID: 26026671.

6: Pereira TS, Boscolo CN, Silva DG, Batlouni SR, Schlenk D, Almeida EA. Anti-androgenic activities of diuron and its metabolites in male Nile tilapia (Oreochromis niloticus). Aquat Toxicol. 2015 Jul;164:10-5. doi: 10.1016/j.aquatox.2015.04.013. Epub 2015 Apr 13. PubMed PMID: 25930013.

7: Da Rocha MS, Arnold LL, Dodmane PR, Pennington KL, Qiu F, De Camargo JL, Cohen SM. Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology. 2013 Dec 15;314(2-3):238-46. doi: 10.1016/j.tox.2013.10.005. Epub 2013 Oct 27. PubMed PMID: 24172598.

8: Rubio-Bellido M, Madrid F, Morillo E, Villaverde J. Assisted attenuation of a soil contaminated by diuron using hydroxypropyl-β-cyclodextrin and organic amendments. Sci Total Environ. 2015 Jan 1;502:699-705. doi: 10.1016/j.scitotenv.2014.09.052. Epub 2014 Oct 11. PubMed PMID: 25310830.

9: Tasmin R, Shimasaki Y, Tsuyama M, Qiu X, Khalil F, Okino N, Yamada N, Fukuda S, Kang IJ, Oshima Y. Elevated water temperature reduces the acute toxicity of the widely used herbicide diuron to a green alga, Pseudokirchneriella subcapitata. Environ Sci Pollut Res Int. 2014 Jan;21(2):1064-70. doi: 10.1007/s11356-013-1989-y. Epub 2013 Jul 20. PubMed PMID: 23872901.

10: Dupraz V, Coquillé N, Ménard D, Sussarellu R, Haugarreau L, Stachowski-Haberkorn S. Microalgal sensitivity varies between a diuron-resistant strain and two wild strains when exposed to diuron and irgarol, alone and in mixtures. Chemosphere. 2016 May;151:241-52. doi: 10.1016/j.chemosphere.2016.02.073. Epub 2016 Mar 15. PubMed PMID: 26945240.

11: Ellegaard-Jensen L, Knudsen BE, Johansen A, Albers CN, Aamand J, Rosendahl S. Fungal-bacterial consortia increase diuron degradation in water-unsaturated systems. Sci Total Environ. 2014 Jan 1;466-467:699-705. doi: 10.1016/j.scitotenv.2013.07.095. Epub 2013 Aug 25. PubMed PMID: 23973535.

12: Barranger A, Akcha F, Rouxel J, Brizard R, Maurouard E, Pallud M, Menard D, Tapie N, Budzinski H, Burgeot T, Benabdelmouna A. Study of genetic damage in the Japanese oyster induced by an environmentally-relevant exposure to diuron: evidence of vertical transmission of DNA damage. Aquat Toxicol. 2014 Jan;146:93-104. doi: 10.1016/j.aquatox.2013.10.032. Epub 2013 Nov 7. PubMed PMID: 24291084.

13: Mansano AS, Moreira RA, Pierozzi M, Oliveira TMA, Vieira EM, Rocha O, Regali-Seleghim MH. Effects of diuron and carbofuran pesticides in their pure and commercial forms on Paramecium caudatum: The use of protozoan in ecotoxicology. Environ Pollut. 2016 Jun;213:160-172. doi: 10.1016/j.envpol.2015.11.054. Epub 2016 Feb 16. PubMed PMID: 26890484.

14: Da Rocha MS, Arnold LL, De Oliveira ML, Catalano SM, Cardoso AP, Pontes MG, Ferrucio B, Dodmane PR, Cohen SM, De Camargo JL. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Crit Rev Toxicol. 2014 May;44(5):393-406. doi: 10.3109/10408444.2013.877870. Epub 2014 Feb 11. Review. PubMed PMID: 24512549.

15: Pesce S, Beguet J, Rouard N, Devers-Lamrani M, Martin-Laurent F. Response of a diuron-degrading community to diuron exposure assessed by real-time quantitative PCR monitoring of phenylurea hydrolase A and B encoding genes. Appl Microbiol Biotechnol. 2013 Feb;97(4):1661-8. doi: 10.1007/s00253-012-4318-3. Epub 2012 Aug 2. PubMed PMID: 22854895.

16: Sørensen SR, Juhler RK, Aamand J. Degradation and mineralisation of diuron by Sphingomonas sp. SRS2 and its potential for remediating at a realistic µg L(-1) diuron concentration. Pest Manag Sci. 2013 Nov;69(11):1239-44. doi: 10.1002/ps.3490. Epub 2013 Mar 13. PubMed PMID: 23494959.

17: Ali HR, Arifin MM, Sheikh MA, Shazili NA, Bakari SS, Bachok Z. Contamination of diuron in coastal waters around Malaysian Peninsular. Mar Pollut Bull. 2014 Aug 15;85(1):287-91. doi: 10.1016/j.marpolbul.2014.05.049. Epub 2014 Jun 13. PubMed PMID: 24934440.

18: Barranger A, Benabdelmouna A, Dégremont L, Burgeot T, Akcha F. Parental exposure to environmental concentrations of diuron leads to aneuploidy in embryos of the Pacific oyster, as evidenced by fluorescent in situ hybridization. Aquat Toxicol. 2015 Feb;159:36-43. doi: 10.1016/j.aquatox.2014.11.011. Epub 2014 Nov 24. PubMed PMID: 25498420.

19: Coelho-Moreira Jda S, Bracht A, de Souza AC, Oliveira RF, de Sá-Nakanishi AB, de Souza CG, Peralta RM. Degradation of diuron by Phanerochaete chrysosporium: role of ligninolytic enzymes and cytochrome P450. Biomed Res Int. 2013;2013:251354. doi: 10.1155/2013/251354. Epub 2013 Dec 31. PubMed PMID: 24490150; PubMed Central PMCID: PMC3892757.

20: Dages C, Samouëlian A, Negro S, Storck V, Huttel O, Voltz M. Seepage patterns of Diuron in a ditch bed during a sequence of flood events. Sci Total Environ. 2015 Dec 15;537:120-8. doi: 10.1016/j.scitotenv.2015.07.130. Epub 2015 Aug 14. PubMed PMID: 26282746.