Phenethicillin potassium

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Hodoodo CAT#: H558041

CAS#: 132-93-4 (potassium)

Description: Phenethicillin potassium is a potassium salt form of phenethicillin, a narrow-spectrum, beta-lactamase-sensitive penicillin with antibacterial activity.

Chemical Structure

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Phenethicillin potassium
CAS# 132-93-4 (potassium)
Instruction

Theoretical Analysis

Hodoodo Cat#: H558041
Name: Phenethicillin potassium
CAS#: 132-93-4 (potassium)
Chemical Formula: C17H19KN2O5S
Exact Mass: 402.07
Molecular Weight: 402.510
Elemental Analysis: C, 50.73; H, 4.76; K, 9.71; N, 6.96; O, 19.87; S, 7.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 147-55-7 (free)   132-93-4 (potassium)    

Synonym: Phenethicillin potassium; Phenethicillin-potassium; Phenethicillinpotassium; ALPHA-PHENOXYETHYLPENICILLINIC ACID POTASSIUM SALT; PHENETHICILLIN POTASSIUM; PHENETHICILLIN POTASSIUM SALT;

IUPAC/Chemical Name: 3,3-Dimethyl-7-oxo-6-((1-oxo-2-phenoxypropyl)amino)-4-thia-1-azabicyclo(3.2.0)-heptane-2-carboxylic acid potassium salt

InChi Key: ORMNNUPLFAPCFD-UHFFFAOYSA-M

InChi Code: InChI=1S/C17H20N2O5S.K/c1-9(24-10-7-5-4-6-8-10)13(20)18-11-14(21)19-12(16(22)23)17(2,3)25-15(11)19;/h4-9,11-12,15H,1-3H3,(H,18,20)(H,22,23);/q;+1/p-1

SMILES Code: O=C(C(C(C)(C)SC1C2NC(C(OC3=CC=CC=C3)C)=O)N1C2=O)[O-].[K+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 402.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: MARTIN WJ, NICHOLS DR. Penicillin V and phenethicillin potassium in serum: comparison of concentrations and of antibacterial effects. Proc Staff Meet Mayo Clin. 1960 Sep 28;35:577-84. PubMed PMID: 13767422.

2: CAMPEAU L, LEFEBVRE M. Treatment of bacterial endocarditis by oral phenethicillin potassium (Syncillin). Can Med Assoc J. 1961 Mar 11;84:535-9. PubMed PMID: 13690283; PubMed Central PMCID: PMC1939332.

3: SABATINE JW, KARP A, FREEMAN SL. Phenethicillin vs. potassium penicillin G for ear, nose, and throat infections. Eye Ear Nose Throat Mon. 1963 May;42:53-4. PubMed PMID: 13975864.

4: Khan KA, Musikabhumma P. Effect of slugging pressure on the properties of granules and tablets prepared from potassium phenethicillin. J Pharm Pharmacol. 1981 Oct;33(10):627-31. PubMed PMID: 6117614.

5: Stenlake JB, Wood GC, Mital HC, Stewart S. The assay of potassium 6-(L-(+)- -phenoxypropionamido)penicillanate and 6-(D-(+)- -phenoxypropionamido)penicillanate in phenethicillin potassium by circular dichroism spectrometry. Analyst. 1972 Aug;97(157):639-43. PubMed PMID: 4341370.

6: GALIMI R. Bacterial infections of the ear, nose and throat treated with oral penicillin (potassium phenethicillin). Eye Ear Nose Throat Mon. 1961 Jul;40:475-6. PubMed PMID: 13703075.

7: Alpar HO, Walters V. The prolongation of the in vitro dissolution of a soluble drug (phenethicillin potassium) by microencapsulation with ethyl cellulose. J Pharm Pharmacol. 1981 Jul;33(7):419-22. PubMed PMID: 6115027.

8: Alpar OH. Sustained-release characteristics of tablets of ethylcellulose microcapsules containing potassium phenethicillin. Farmaco Prat. 1981 Aug;36(8):366-73. PubMed PMID: 6791959.

9: SCHWARTZ MA, GRANATEK AP, BUCKWALTER FH. Stability of potassium phenethicillin. I. Kinetics of degradation in aqueous solution. J Pharm Sci. 1962 Jun;51:523-6. PubMed PMID: 13909711.

10: CAMPEAU L, LEFEBVRE M. [Oral treatment of malignant streptococcal endocarditis by potassium phenethicillin: 10 cases]. Union Med Can. 1963 Aug;92:873-80. French. PubMed PMID: 14018160.

11: Marty JJ, Hersey JA. Absorption of phenethicillin from oral paediatric formulations. Med J Aust. 1975 Mar 22;1(12):382-4. PubMed PMID: 806767.

12: Wilson WL, Avdovich HW, Hughes DW, Buchanan GW. Application of proton and 13C-NMR spectroscopy to estimation of diastereoisomer ratio in phenethicillin. J Pharm Sci. 1977 Aug;66(8):1079-83. PubMed PMID: 408475.

13: PERRON YG, CRAST LB, GOTTSTEIN WJ, MINOR WF, CHENEY LC. Synthesis of potassium penicillin-152 [potassium (alpha-phenoxyethyl)-penicillin] and both diastereoisomers. Antibiot Annu. 1959-1960;7:107-10. PubMed PMID: 13854294.

14: Musikabhumma P, Khan KA. Effect of slugging pressure on the properties of granules and tablets prepared from potassium phenethicillin [proceedings]. J Pharm Pharmacol. 1979 Dec;31 Suppl:75P. PubMed PMID: 42753.

15: BREESE BB, DISNEY FA, TALPEY WB. BETA-HEMOLYTIC STREPTOCOCCAL INFECTIONS IN CHILDREN. COMPARISON OF THE THERAPEUTIC EFFECTIVENESS OF POTASSIUM PENICILLIN G, TETRACYCLINE PHOSPHATE COMPLEX, AND DEMETHYLCHLORTETRACYCLINE. Am J Dis Child. 1964 Mar;107:232-9. PubMed PMID: 14095108.

16: PINDELL MH, TISCH DE, HOEKSTRA JB, REIFFENSTEIN JC. Pharmacological studies on potassium penicillin-152 [potassium (alpha-phenoxyethyl)-penicillin]. Antibiot Annu. 1959-1960;7:119-26. PubMed PMID: 13854362.

17: GOUREVITCH A, HUNT GA, LEIN J. Microbiological studies on potassium penicillin-152 [potassium (alpha-phenoxyethyl)-penicillin]. Antibiot Annu. 1959-1960;7:111-8. PubMed PMID: 13851448.

18: CRONK GA, NAUMANN DE, ALBRIGHT H, WHEATLEY WB. Laboratory and clinical studies with potassium penicillin-152 [potassium (alpha-phenoxyethyl)-penicillin]. Antibiot Annu. 1959-1960;7:133-45. PubMed PMID: 13849468.

19: CRONK GA, WHEATLEY WB, FELLERS GF, ALBRIGHT H. The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract. Am J Med Sci. 1960 Aug;240:219-25. PubMed PMID: 13812969.

20: Overbosch D, Mattie H, van Furth R. Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Br J Clin Pharmacol. 1985 May;19(5):657-68. PubMed PMID: 3924086; PubMed Central PMCID: PMC1463849.