SD-1029
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562753

CAS#: 118372-34-2

Description: SD-1029 is a cell-permeable selective JAK2 inhibitor.


Chemical Structure

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SD-1029
CAS# 118372-34-2

Theoretical Analysis

Hodoodo Cat#: H562753
Name: SD-1029
CAS#: 118372-34-2
Chemical Formula: C25H32Br2Cl2N2O3
Exact Mass: 0.00
Molecular Weight: 639.250
Elemental Analysis: C, 46.97; H, 5.05; Br, 25.00; Cl, 11.09; N, 4.38; O, 7.51

Price and Availability

Size Price Availability Quantity
5mg USD 325 2 Weeks
10mg USD 550 2 Weeks
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Synonym: SD-1029; SD 1029; SD1029; NSC371488; NSC-371488; NSC 371488; JAK2 Inhibitor III;

IUPAC/Chemical Name: 9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione dihydrobromide

InChi Key: INKLAKXQHDQKKZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H30Cl2N2O3.2BrH/c1-28(2)12-15-6-9-19-22(24(15)30)21(14-5-8-17(26)18(27)11-14)23-20(32-19)10-7-16(25(23)31)13-29(3)4;;/h5,8,11,15-16,21H,6-7,9-10,12-13H2,1-4H3;2*1H

SMILES Code: O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 639.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zelano J, Larsson D, Kumlien E, Åsberg S. Pre-stroke seizures: A nationwide register-based investigation. Seizure. 2017 Jul;49:25-29. doi: 10.1016/j.seizure.2017.05.010. Epub 2017 May 17. PubMed PMID: 28544888.

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6: Andina N, Didichenko S, Schmidt-Mende J, Dahinden CA, Simon HU. Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils. J Allergy Clin Immunol. 2009 Mar;123(3):603-11. doi: 10.1016/j.jaci.2008.12.004. Epub 2009 Jan 18. PubMed PMID: 19152965.

7: Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. PubMed PMID: 17121906.