WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591128
CAS#: 4261-14-7
Description: 9-Benzyladenine is a bioactive chemical.
Hodoodo Cat#: H591128
Name: 9-Benzyladenine
CAS#: 4261-14-7
Chemical Formula: C12H11N5
Exact Mass: 225.10
Molecular Weight: 225.260
Elemental Analysis: C, 63.99; H, 4.92; N, 31.09
Synonym: 9-Benzyladenine; NSC 35649; NSC-35649; NSC35649
IUPAC/Chemical Name: 9-Benzyladenine
InChi Key: MRHCSNNEUHXNIC-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H11N5/c13-11-10-12(15-7-14-11)17(8-16-10)6-9-4-2-1-3-5-9/h1-5,7-8H,6H2,(H2,13,14,15)
SMILES Code: NC1=C2C(N(CC3=CC=CC=C3)C=N2)=NC=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 225.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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3: Hirota K, Kazaoka K, Sajiki H. Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers. Bioorg Med Chem. 2003 Jul 3;11(13):2715-22. PubMed PMID: 12788345.
4: Reimund JM, Raboisson P, Pinna G, Lugnier C, Bourguignon JJ, Muller CD. Anti-TNF-alpha properties of new 9-benzyladenine derivatives with selective phosphodiesterase-4- inhibiting properties. Biochem Biophys Res Commun. 2001 Oct 26;288(2):427-34. PubMed PMID: 11606060.
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7: Liu DY, Gorrod JW. Effects of cAMP-dependent protein kinase and ATP on N1-oxidation of 9-benzyladenine by animal hepatic microsomes. Life Sci. 2000;66(1):77-88. PubMed PMID: 10658926.
8: Boichot E, Wallace JL, Germain N, Corbel M, Lugnier C, Lagente V, Bourguignon JJ. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derived from 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53. PubMed PMID: 10640302.
9: Liu DY, Liu ZD, el-Ghomari K, Gorrod JW. Metabolism of 9-(2-chlorobenzyl)-, 9-(2-methylbenzyl)- and 9-(2-methoxybenzyl)-adenines by hamster hepatic microsomes. Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):367-73. PubMed PMID: 9512936.
10: Liu DY, Gorrod JW. Solid phase extraction and HPLC determination of 9-benzyladenine and isomeric 9-(nitrobenzyl)adenines and their metabolic N1-oxides present in microsomal incubates. J Pharm Biomed Anal. 1997 Jul;15(11):1741-50. PubMed PMID: 9260671.
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13: Lam SP, Devinsky F, Gorrod JW. Biological N-oxidation of adenine and 9-alkyl derivatives. Eur J Drug Metab Pharmacokinet. 1987 Oct-Dec;12(4):239-43. PubMed PMID: 3449381.
14: Harris DN, Asaad MM, Phillips MB, Goldenberg HJ, Antonaccio MJ. Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J Cyclic Nucleotide Res. 1979;5(2):125-34. PubMed PMID: 221552.
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