WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591144
CAS#: 24168-96-5 (nitrate)
Description: Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.
Hodoodo Cat#: H591144
Name: Isoconazole nitrate
CAS#: 24168-96-5 (nitrate)
Chemical Formula: C18H15Cl4N3O4
Exact Mass: 476.98
Molecular Weight: 479.140
Elemental Analysis: C, 45.12; H, 3.16; Cl, 29.59; N, 8.77; O, 13.36
Related CAS #: 27523-40-6 (free base) 24168-96-5 (nitrate)
Synonym: Isoconazole nitrate; Adestan G100; R 15,454; R15,454; R-15,454; R 15454; R15454; R-15454;
IUPAC/Chemical Name: Imidazole, 1-(2,4-dichloro-beta-((2,6-dichlorobenzyl)oxy)phenethyl)-, mononitrate
InChi Key: NNGQLSIGRSTLLU-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H14Cl4N2O.HNO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
SMILES Code: ClC1=C(C(Cl)=CC=C1)COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.O[N+]([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 479.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Botelho KP, Soares YC, Gonçalves DP, Melo BLA. Figurate erythematous lesion by Microsporum canis in immunosuppressed patient. An Bras Dermatol. 2018 Jan-Feb;93(1):141-142. doi: 10.1590/abd1806-4841.20187094. PubMed PMID: 29641719; PubMed Central PMCID: PMC5871384.
2: Podolska M, Bialecka W, Kulik A, Kwiatkowska-Puchniarz B, Mazurek A. HPLC METHOD FOR SEPARATING ENANTIOMERS OF IMIDAZOLE DERIVATIVES - ANTIFUNGAL COMPOUNDS. Acta Pol Pharm. 2017 May;74(3):777-784. PubMed PMID: 29513946.
3: Veraldi S, Schianchi R, Pontini P, Gorani A. The association of isoconazole-diflucortolone in the treatment of pediatric tinea corporis. J Dermatolog Treat. 2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19. PubMed PMID: 28753055.
4: Bianchi L, Hansel K, Antonelli E, Bellini V, Stingeni L. Contact allergy to isoconazole nitrate with unusual spreading over extensive regions. Contact Dermatitis. 2017 Apr;76(4):243-245. doi: 10.1111/cod.12688. PubMed PMID: 28317189.
5: Ivancic A, Macaev F, Aksakal F, Boldescu V, Pogrebnoi S, Duca G. Preparation of alginate-chitosan-cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds. Beilstein J Nanotechnol. 2016 Aug 24;7:1208-1218. eCollection 2016. PubMed PMID: 27826495; PubMed Central PMCID: PMC5082317.
6: Özkaya E. Patch testing with used and unused personal products: a practical way to show contamination with contact allergens. Contact Dermatitis. 2016 Nov;75(5):328-330. doi: 10.1111/cod.12626. PubMed PMID: 27709699.
7: Erkan D, Kolukırık İ, Acar A, Kandemir H, İlkit M. [A recurrent case of adult favus successfully treated with terbinafine]. Mikrobiyol Bul. 2015 Oct;49(4):619-24. Turkish. PubMed PMID: 26649420.
8: Nagashima M, Yamagishi Y, Mikamo H. Antifungal susceptibilities of Candida species isolated from the patients with vaginal candidiasis. J Infect Chemother. 2016 Feb;22(2):124-6. doi: 10.1016/j.jiac.2015.08.008. Epub 2015 Nov 25. PubMed PMID: 26627336.
9: Falcão EM, Trope BM, Martins NR, Barreiros Mda G, Ramos-E-Silva M. Bilateral Tinea Nigra Plantaris with Good Response to Isoconazole Cream: A Case Report. Case Rep Dermatol. 2015 Oct 28;7(3):306-10. doi: 10.1159/000441602. eCollection 2015 Sep-Dec. PubMed PMID: 26594169; PubMed Central PMCID: PMC4650990.
10: Wan Ibrahim WA, Abd Wahib SM, Hermawan D, Sanagi MM, Aboul-Enein HY. Separation of selected imidazole enantiomers using dual cyclodextrin system in micellar electrokinetic chromatography. Chirality. 2013 Jun;25(6):328-35. doi: 10.1002/chir.22156. PubMed PMID: 23716264.
11: Veraldi S. Rapid relief of intertrigo-associated pruritus due to Candida albicans with isoconazole nitrate and diflucortolone valerate combination therapy. Mycoses. 2013 May;56 Suppl 1:41-3. doi: 10.1111/myc.12058. PubMed PMID: 23574026.
12: Piergiorgio M. Effective treatment of erythrasma-associated inflammation and pruritus with isoconazole nitrate and diflucortolone valerate combination therapy. Mycoses. 2013 May;56 Suppl 1:38-40. doi: 10.1111/myc.12046. PubMed PMID: 23574025.
13: Czaika VA, Lam PA. Trichophyton mentagrophytes cause underestimated contagious zoophilic fungal infection. Mycoses. 2013 May;56 Suppl 1:33-7. doi: 10.1111/myc.12069. PubMed PMID: 23574024.
14: Czaika VA. Effective treatment of tinea corporis due to Trichophyton mentagrophytes with combined isoconazole nitrate and diflucortolone valerate therapy. Mycoses. 2013 May;56 Suppl 1:30-2. doi: 10.1111/myc.12068. PubMed PMID: 23574023.
15: Czaika VA. Misdiagnosed zoophile tinea faciei and tinea corporis effectively treated with isoconazole nitrate and diflucortolone valerate combination therapy. Mycoses. 2013 May;56 Suppl 1:26-9. doi: 10.1111/myc.12057. PubMed PMID: 23574022.
16: Friedrich M. Inflammatory tinea pedis with bacterial superinfection effectively treated with isoconazole nitrate and diflucortolone valerate combination therapy. Mycoses. 2013 May;56 Suppl 1:23-5. doi: 10.1111/myc.12056. PubMed PMID: 23574021.
17: Czaika VA, Siebenbrock J, Czekalla F, Zuberbier T, Sieber MA. Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate. Mycoses. 2013 May;56 Suppl 1:16-22. doi: 10.1111/myc.12055. PubMed PMID: 23574020.
18: Veraldi S. Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Mycoses. 2013 May;56 Suppl 1:3-15. doi: 10.1111/myc.12054. Review. PubMed PMID: 23574019.
19: Rossetto AL, Cruz RC, Haddad Junior V. Double-blind study with topical Isoconazole and Terbinafine for the treatment of one patient with bilateral Tinea nigra plantaris and suggestions for new differential diagnosis. Rev Inst Med Trop Sao Paulo. 2013 Mar-Apr;55(2):125-8. PubMed PMID: 23563768.
20: Can C, Yazicioglu M, Ozdemir PG, Kilavuz S, Tastekin E. Symmetrical drug-related intertriginous and flexural exanthema induced by two different antibiotics. Allergol Immunopathol (Madr). 2014 Mar-Apr;42(2):173-5. doi: 10.1016/j.aller.2012.10.005. Epub 2012 Dec 17. PubMed PMID: 23253684.
