WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562786
CAS#: 1646499-97-9
Description: ML382 is a potent and selective positive allosteric modulator of MrgX1.
Hodoodo Cat#: H562786
Name: ML382
CAS#: 1646499-97-9
Chemical Formula: C18H20N2O4S
Exact Mass: 360.11
Molecular Weight: 360.428
Elemental Analysis: C, 59.98; H, 5.59; N, 7.77; O, 17.76; S, 8.89
Synonym: ML382; ML-382; ML 382;
IUPAC/Chemical Name: 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide
InChi Key: RCSLEKLNDJJJLF-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H20N2O4S/c1-2-24-17-10-6-5-9-16(17)19-18(21)14-7-3-4-8-15(14)20-25(22,23)13-11-12-13/h3-10,13,20H,2,11-12H2,1H3,(H,19,21)
SMILES Code: O=C(NC1=CC=CC=C1OCC)C2=CC=CC=C2NS(=O)(C3CC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 360.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wen W, Wang Y, McManus O, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. Discovery and characterization of a small molecule allosteric agonist of MrgX1. 2013 Dec 15 [updated 2015 Feb 11]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK280040/ PubMed PMID: 25834894.