Dihexyverine HCl
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Hodoodo CAT#: H596235

CAS#: 5588-25-0 (HCl)

Description: Dihexyverine HCl is an antimuscarinic with effects similar to those of atropine. it has been given in the symptomatic treatment of gastrointestinal spasm.


Chemical Structure

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Dihexyverine HCl
CAS# 5588-25-0 (HCl)

Theoretical Analysis

Hodoodo Cat#: H596235
Name: Dihexyverine HCl
CAS#: 5588-25-0 (HCl)
Chemical Formula: C20H36ClNO2
Exact Mass: 357.24
Molecular Weight: 357.960
Elemental Analysis: CC, 67.11; H, 10.14; Cl, 9.90; N, 3.91; O, 8.94

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 weeks
10mg USD 400 2 weeks
50mg USD 950 2 weeks
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Related CAS #: 561-77-3 (free base)   5588-25-0 (HCl)  

Synonym: Dihexyverine HCl; Diverine; Dihexyverine hydrochloride; Neospasmina; Olimplex; Seclin; Spasmodex; JL 1078;

IUPAC/Chemical Name: 2-(piperidin-1-yl)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride

InChi Key: AQFATCCHOXBYNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H35NO2.ClH/c22-19(23-17-16-21-14-8-3-9-15-21)20(12-6-2-7-13-20)18-10-4-1-5-11-18;/h18H,1-17H2;1H

SMILES Code: O=C(C1(C2CCCCC2)CCCCC1)OCCN3CCCCC3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: BUCHEL L, LIBLAU L. [MECHANISM OF THE PHENOMENA OF SYNERGISM OF EXPERIMENTAL SLEEP. I. STUDY OF THE ASSOCIATIONS CHLORPROMAZINE-HEXOBARBITOL, DIHEXYVERINE-HEXOBARBITAL, IN MICE]. Arch Sci Physiol (Paris). 1964;18:339-61. French. PubMed PMID: 14251293.

2: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Can Med Assoc J. 1962 Nov 24;87:1121-3. French. PubMed PMID: 13944939; PubMed Central PMCID: PMC1849825.

3: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Union Med Can. 1962 Aug;91:832-6. French. PubMed PMID: 13892604.

4: DELECOUR, VITSE, MONNIER. [Clinical experimentation with an antispasmodic, "Dihexyverine", in obstetrical practice]. Lille Med. 1962 Feb;7:143-6. French. PubMed PMID: 13885120.

5: BILWEIS J. [Experimental study on the use of dihexyverine in obstetrical labor by the physiological accelerated labor method]. Concours Med. 1958 Mar 8;80(10):1193-5. French. PubMed PMID: 13511938.

6: MEUNIER H. [Use of dihexyverine in gynecology]. Gaz Med Fr. 1957 Sep 25;64(18):1533-4. French. PubMed PMID: 13480436.

7: ROLLIN G. [Trial therapy of spastic cough with a new synthetic antispasmodic: dihexyverine]. Gaz Med Fr. 1955 Dec 25;62(24):1962-3. French. PubMed PMID: 13294387.

8: FRANCK C, LAMARCHE M, ROZE P. [Modifications in the resistance to oxygen deficiency in the guinea pig after administration of dihexyverine]. C R Seances Soc Biol Fil. 1955 Dec;149(23-24):2201-2. French. PubMed PMID: 13317334.

9: SIMON C, CARRAUD G. [Contribution to the treatment of enteropathies; digestive application of a new synthetic spasmolytic--dihexyverine]. Sem Hop. 1955 Mar 20;31(18/2):91-3. French. PubMed PMID: 14373023.

10: FRANCK C, GRANDPIERRE R. [Effect of dihexyverine on histaminic bronchospasm in guinea pigs]. Rev Pathol Gen Physiol Clin. 1955 Mar;55(666):387-9. French. PubMed PMID: 14396051.

11: LE BARS H, MAGNE J. [Pharmacodynamic study of [bicyclohexyl]-1-carboxylic acid 2-piperidino-ethyl ester hydrochloride (dihexyverine)]. Therapie. 1955;10(3):514-25. French. PubMed PMID: 13299206.