ARS-853
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584444

CAS#: 1629268-00-3

Description: ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

Chemical Structure

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ARS-853
CAS# 1629268-00-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H584444
Name: ARS-853
CAS#: 1629268-00-3
Chemical Formula: C22H29ClN4O3
Exact Mass: 432.19
Molecular Weight: 432.949
Elemental Analysis: C, 61.03; H, 6.75; Cl, 8.19; N, 12.94; O, 11.09

Price and Availability

Size Price Availability Quantity
1mg USD 350 2 Weeks
5mg USD 750 2 Weeks
10mg USD 1250 2 Weeks
25mg USD 1850 2 Weeks
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Synonym: ARS-853; ARS853; ARS 853

IUPAC/Chemical Name: 2-Propen-1-one, 1-[3-[4-[2-[[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1- piperazinyl]-1-azetidinyl]-

InChi Key: IPFOCHMOYUMURK-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H29ClN4O3/c1-3-20(29)27-13-15(14-27)25-6-8-26(9-7-25)21(30)12-24-18-10-16(22(2)4-5-22)17(23)11-19(18)28/h3,10-11,15,24,28H,1,4-9,12-14H2,2H3

SMILES Code: C=CC(N1CC(N2CCN(C(CNC3=CC(C4(C)CC4)=C(Cl)C=C3O)=O)CC2)C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 432.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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[1] Patricelli MP, et al. Cancer Discov. 2016, 6(3):316-29.

[2] Lito P, et al. Science. 2016, 351(6273):604-8.