Cortisone
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558333

CAS#: 53-06-5

Description: Cortisone is a naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE.

Chemical Structure

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Cortisone
CAS# 53-06-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H558333
Name: Cortisone
CAS#: 53-06-5
Chemical Formula: C21H28O5
Exact Mass: 360.19
Molecular Weight: 360.450
Elemental Analysis: C, 69.98; H, 7.83; O, 22.19

Price and Availability

Size Price Availability Quantity
250mg USD 250 2 Weeks
1g USD 450 2 Weeks
5g USD 850 2 Weeks
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Synonym: Cortisone; NSC 9703; NSC9703; NSC-9703;

IUPAC/Chemical Name: Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy

InChi Key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N

InChi Code: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

SMILES Code: C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])C2=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 360.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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18: Mitsui T, Araki A, Goudarzi H, Miyashita C, Ito S, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K. Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health. Am J Hum Biol. 2018 Apr 6:e23127. doi: 10.1002/ajhb.23127. [Epub ahead of print] PubMed PMID: 29624785.

19: Qi J, Wang W, Zhu Q, He Y, Lu Y, Wang Y, Li X, Chen ZJ, Sun Y. Local Cortisol Elevation Contributes to Endometrial Insulin Resistance in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2018 Mar 30. doi: 10.1210/jc.2017-02459. [Epub ahead of print] PubMed PMID: 29618067.

20: Carvajal CA, Tapia-Castillo A, Valdivia CP, Allende F, Solari S, Lagos CF, Campino C, Martínez-Aguayo A, Vecchiola A, Pinochet C, Godoy C, Iturrieta V, Baudrand R, Fardella CE. Serum Cortisol and Cortisone as potential biomarkers of Partial 11β-hydroxysteroid dehydrogenase type-2 Deficiency. Am J Hypertens. 2018 Mar 30. doi: 10.1093/ajh/hpy051. [Epub ahead of print] PubMed PMID: 29617893.