WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562867
CAS#: 337500-87-5
Description: LDN-0028574 is an inhibitor of SIRT1. It also acts as an inhibitor of the human MDM2-p53 interaction.
Hodoodo Cat#: H562867
Name: LDN-0028574
CAS#: 337500-87-5
Chemical Formula: C21H14N4O4S
Exact Mass: 418.07
Molecular Weight: 418.420
Elemental Analysis: C, 60.28; H, 3.37; N, 13.39; O, 15.29; S, 7.66
This product is not in stock, which may be available by custom synthesis.
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Synonym: LDN-0028574; LDN 0028574; LDN0028574; LDN-28574; SIRT1-Inhibitor-I1; SIRT1-I1; LDN 28574; LDN28574; SIRT1I1; SIRT1 I1; SIRT1 Inhibitor I1;
IUPAC/Chemical Name: 2-Amino-6-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile
InChi Key: YBZQMVDFRWVFTH-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H14N4O4S/c22-8-14-19(11-1-4-13(26)5-2-11)15(9-23)21(25-20(14)24)30-10-18(29)12-3-6-16(27)17(28)7-12/h1-7,26-28H,10H2,(H2,24,25)
SMILES Code: N#CC1=C(C2=CC=C(O)C=C2)C(C#N)=C(SCC(C3=CC=C(O)C(O)=C3)=O)N=C1N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 418.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
