Diethadione

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H596404

CAS#: 702-54-5

Description: Diethadione is a respiratory analeptic.

Chemical Structure

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Diethadione
CAS# 702-54-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H596404
Name: Diethadione
CAS#: 702-54-5
Chemical Formula: C8H13NO3
Exact Mass: 171.09
Molecular Weight: 171.190
Elemental Analysis: C, 56.13; H, 7.65; N, 8.18; O, 28.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Diethadione; Diethadionum; HSDB 5514; L 1811; L-1811; L1811; NSC 169418; NSC169418; NSC-169418;

IUPAC/Chemical Name: 5,5-diethyl-1,3-oxazinane-2,4-dione

InChi Key: ORTYMGHCFWKXHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H13NO3/c1-3-8(4-2)5-12-7(11)9-6(8)10/h3-5H2,1-2H3,(H,9,10,11)

SMILES Code: O=C(N1)OCC(CC)(CC)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 171.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lorizio A, Gandini S. [Inhibiting action of gamma-amino-butyrylcholine on convulsive crises and on electroencephalographic paroxysms evoked by diethadione, by hyperpnea and by intermittent light stimulation in epileptic subjects]. Riv Neurobiol. 1966 Apr-Jun;12(2):153-65. Italian. PubMed PMID: 4381273.

2: RADERMECKER M, MARCELLE R, PETIT JM, MELON J. [INFLUENCE OF A RESPIRATORY ANALEPTIC, DIETHADIONE, ON VENTILATORY MECHANICAL WORK AFTER SODIUM PENTOTHAL INJECTION]. Pathol Biol. 1964 Aug-Sep;12:859-63. French. PubMed PMID: 14200510.

3: FADIGA E, GESSI T, MAFFII G. [ELECTROPHYSIOLOGICAL RESEARCH ON THE ACTION OF AN OXAZINE-DIONE DERIVATIVE (DIETHADIONE) ON THE RESPIRATORY CENTERS]. Arch Sci Biol (Bologna). 1964 Apr-Jun;48:149-62. Italian. PubMed PMID: 14210398.

4: SFORZA I. [DIETHADIONE IN FLUOTHANE ANESTHESIA IN EXTRA-ABDOMINAL UROLOGICAL AND OPHTHALMIC SURGERY]. Acta Anaesthesiol. 1964 Mar-Apr;15:169-87. Italian. PubMed PMID: 14154986.

5: RADERMECKER M, MARCELLE R, DALIMIER N, OGER A. [INFLUENCE OF ORAL DIETHADIONE ADMINISTRATION ON THE HYPERCAPNIA OF THE CHRONIC PULMONARY PATIENT]. Acta Tuberc Pneumol Belg. 1964 Jan-Feb;55:33-41. French. PubMed PMID: 14175172.

6: VERNONI S. [THE USE OF 4-CHLOROTESTOSTERONE ACETATE AND OF DIETHADIONE IN PATIENTS WITH POSTOPERATIVE HYPOTENSION]. Riv Patol Clin. 1963 Aug;18:431-41. Italian. PubMed PMID: 14083555.

7: FASSINA G. [CLINICO-INSTRUMENTAL EVALUATION OF THE RESPIRATORY ANALEPTIC ACTION OF DIETHADIONE]. Gazz Int Med Chir. 1963 Jul 31;68:1496-511. Italian. PubMed PMID: 14047717.

8: CAZZOLA D, MORELLI V, ZORCOLO S. [ON THE CENTRAL STIMULATION OF RESPIRATION AND CIRCULATION IN GYNECOLOGICAL OPERATIONS AND OBSTRETRICS AND IN ASPHYXIA NEONATORUM. CLINICAL EXPERIENCE WITH DIETHADIONE]. Minerva Ginecol. 1963 Jun 15;15:559-63. Italian. PubMed PMID: 14047382.

9: WITTGENS A. [Tocen (diethadione): a new analeptic]. Boll Chim Farm. 1963 Feb;102:88-90. Italian. PubMed PMID: 14001416.

10: RIZZI R, NICOLIS FB. [Clinico-statistical considerations on some barbiturate antagonists with special reference to diethadione]. Sem Med. 1962 Oct 29;121:1635-45. Spanish. PubMed PMID: 13974174.

11: MARTINO OE. [Diethadione, a new analeptic]. Dia Med. 1962 May 7;34:660-2. Spanish. PubMed PMID: 14470538.

12: CALLIGARI G, ROSSI W, BARBIERI G. [Considerations on the use of diethadione in anesthesia]. Acta Anaesthesiol. 1962 May-Jun;13:207-21. Italian. PubMed PMID: 14017918.

13: DAMENO R. [Diethadione: a new analeptic. Its use in newborn infants]. Sem Med. 1962 Apr 16;120:703-4. Spanish. PubMed PMID: 13883288.

14: SANTIAGO CURCI A. [Clinical trials of diethadione]. Dia Med. 1962 Mar 19;34:320-2. Spanish. PubMed PMID: 14497046.

15: NICOLIS FB, ACOCELLA G, GHISELLINI A, CENACCHI G, ALBERTI G. A study of some pharmacological properties of diethadione in man. Chemotherapia (Basel). 1962;4:485-505. PubMed PMID: 14479573.