WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596452
CAS#: 104112-82-5
Description: Phellodendrine Chloride is an alkaloid isolated from the Phellodrndron amurensis, which shows activity as an immunosuppressor against the cellular immune response.
Hodoodo Cat#: H596452
Name: Phellodendrine chloride
CAS#: 104112-82-5
Chemical Formula: C20H24ClNO4
Exact Mass: 0.00
Molecular Weight: 377.865
Elemental Analysis: C, 63.57; H, 6.40; Cl, 9.38; N, 3.71; O, 16.94
Synonym: Phellodendrine chloride; l-(-)-N-Methylcoreximine;
IUPAC/Chemical Name: (13aS)-2,11-dihydroxy-3,10-dimethoxy-7-methyl-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
InChi Key: DGLDSNPMIYUWGN-OOJQBDKLSA-N
InChi Code: InChI=1S/C20H23NO4.ClH/c1-21-5-4-12-8-19(24-2)18(23)10-15(12)16(21)6-13-7-17(22)20(25-3)9-14(13)11-21;/h7-10,16H,4-6,11H2,1-3H3,(H-,22,23);1H/t16-,21?;/m0./s1
SMILES Code: C[N+]12CCc3c([C@@H]1Cc4c(C2)cc(OC)c(O)c4)cc(O)c(OC)c3.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 377.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yin F, Li L, Li X, Lu T, Li W, Cai B, Yin W. DECOCTION PROCESS OPTIMIZATION AND QUALITY EVALUATION OF YI-HUANG DECOCTION BY HPLC FINGERPRINT ANALYSIS. Acta Pol Pharm. 2016 Jul;73(4):855-864. PubMed PMID: 29648711.
2: Zhang Y, Zhang ZP, Zhang Z, Bi CJ, Liu HT, Zhang Q, Huang SX, Zhang BG, Chen Y, Suo FM. [Regional characteristic analysis of alkaloids and chlorogenic acid in wild Phellodendri Amurensis Cortex]. Zhongguo Zhong Yao Za Zhi. 2016 May;41(10):1797-1802. doi: 10.4268/cjcmm20161006. Chinese. PubMed PMID: 28895323.
3: Mori H, Fuchigami M, Inoue N, Nagai H, Koda A, Nishioka I. Principle of the bark of Phellodendron amurense to suppress the cellular immune response. Planta Med. 1994 Oct;60(5):445-9. PubMed PMID: 7997475.