WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596461
CAS#: 1187-56-0
Description: Selenomethionine Se 75 is a Radioactive Agent used as a Diagnostic Aid (Pancreas Function Determination).
Hodoodo Cat#: H596461
Name: Selenomethionine Se 75
CAS#: 1187-56-0
Chemical Formula: C5H11NO275Se
Exact Mass: 192.00
Molecular Weight: 192.070
Elemental Analysis: C, 31.27; H, 5.77; N, 7.29; O, 16.66; Se, 39.01
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Selenomethionine Se 75; Selenomethionine (75 Se); Selenomethionine (75Se); Selenomethionine se 75; Sethotope;
IUPAC/Chemical Name: (S)-2-amino-4-(methylselanyl-75Se)butanoic acid
InChi Key: RJFAYQIBOAGBLC-ZEMBQCNESA-N
InChi Code: InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i9-4
SMILES Code: O=C(O)[C@@H](N)CC[75Se]C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 192.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhu Y, Ren B, Li H, Lin Z, Bañuelos G, Li L, Zhao G, Guo Y. Biosynthesis of selenium nanoparticles and effects of selenite, selenate, and selenomethionine on cell growth and morphology in Rahnella aquatilis HX2. Appl Microbiol Biotechnol. 2018 May 27. doi: 10.1007/s00253-018-9060-z. [Epub ahead of print] PubMed PMID: 29806064.
2: Flood DT, Yan NL, Dawson PE. Post Translational Backbone Engineering through Selenomethionine Mediated Incorporation of Freidinger Lactams. Angew Chem Int Ed Engl. 2018 May 23. doi: 10.1002/anie.201804885. [Epub ahead of print] PubMed PMID: 29797386.
3: Rohn I, Marschall TA, Kroepfl N, Jensen KB, Aschner M, Tuck S, Kuehnelt D, Schwerdtle T, Bornhorst J. Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans. Metallomics. 2018 May 17. doi: 10.1039/c8mt00066b. [Epub ahead of print] PubMed PMID: 29770420.
4: Wang W, Lee S, Hung SSO, Deng DF. Responses of heat shock protein 70 and caspase-3/7 to dietary selenomethionine in juvenile white sturgeon. Anim Nutr. 2016 Mar;2(1):45-50. doi: 10.1016/j.aninu.2016.02.001. Epub 2016 Mar 15. PubMed PMID: 29766994; PubMed Central PMCID: PMC5940976.
5: Zoidis E, Seremelis I, Kontopoulos N, Danezis GP. Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins. Antioxidants (Basel). 2018 May 14;7(5). pii: E66. doi: 10.3390/antiox7050066. Review. PubMed PMID: 29758013.
6: Finger JW Jr, Hamilton MT, Kelley MD, Zhang Y, Kavazis AN, Glenn TC, Tuberville TD. Dietary Selenomethionine Administration and Its Effects on the American Alligator (Alligator mississippiensis): Oxidative Status and Corticosterone Levels. Arch Environ Contam Toxicol. 2018 May 8. doi: 10.1007/s00244-018-0530-1. [Epub ahead of print] PubMed PMID: 29737374.
7: Falk M, Bernhoft A, Framstad T, Salbu B, Wisløff H, Kortner TM, Kristoffersen AB, Oropeza-Moe M. Effects of dietary sodium selenite and organic selenium sources on immune and inflammatory responses and selenium deposition in growing pigs. J Trace Elem Med Biol. 2018 Mar 8. pii: S0946-672X(17)30964-1. doi: 10.1016/j.jtemb.2018.03.003. [Epub ahead of print] PubMed PMID: 29673733.
8: Ponton DE, Fortin C, Hare L. Organic Selenium, Selenate and Selenite Accumulation by Lake Plankton and the Alga Chlamydomonas reinhardtii at Different pH and Sulfate Concentrations. Environ Toxicol Chem. 2018 Apr 19. doi: 10.1002/etc.4158. [Epub ahead of print] PubMed PMID: 29672902.
9: Saffari S, Keyvanshokooh S, Zakeri M, Johari SA, Pasha-Zanoosi H, Mozanzadeh MT. Effects of dietary organic, inorganic, and nanoparticulate selenium sources on growth, hemato-immunological, and serum biochemical parameters of common carp (Cyprinus carpio). Fish Physiol Biochem. 2018 Apr 16. doi: 10.1007/s10695-018-0496-y. [Epub ahead of print] PubMed PMID: 29663181.
10: Donadio JLS, Rogero MM, Guerra-Shinohara EM, Barbosa F Jr., Desmarchelier C, Borel P, Sneddon AA, Hesketh JE, Cozzolino SMF. Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study). Clin Nutr. 2018 Mar 23. pii: S0261-5614(18)30123-7. doi: 10.1016/j.clnu.2018.03.011. [Epub ahead of print] PubMed PMID: 29609868.
11: Wang W, Zhao Y, Wang H, Yang B. Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions. Protein Sci. 2018 Apr 1. doi: 10.1002/pro.3418. [Epub ahead of print] PubMed PMID: 29607555.
12: Virani NA, Thavathiru E, McKernan P, Moore K, Benbrook DM, Harrison RG. Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer. Cancer Lett. 2018 Jul 1;425:174-182. doi: 10.1016/j.canlet.2018.03.027. Epub 2018 Mar 21. PubMed PMID: 29574275.
13: Vu DL, Ranglová K, Hájek J, Hrouzek P. Quantification of methionine and selenomethionine in biological samples using multiple reaction monitoring high performance liquid chromatography tandem mass spectrometry (MRM-HPLC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:36-44. doi: 10.1016/j.jchromb.2018.03.012. Epub 2018 Mar 9. PubMed PMID: 29558738.
14: Čadková Z, Száková J, Tremlová J, Kopecký O, Žíla O, Tlustoš P. Metabolic transformation and urinary excretion of selenium (Se) in rats fed a Se-enriched defatted rapeseed (Brassica napus, L.) diet. Metallomics. 2018 Apr 25;10(4):579-586. doi: 10.1039/C7MT00325K. PubMed PMID: 29557441.
15: Mazokopakis E. Differentiated thyroid cancer and selenium supplements for protection of salivary glands from (131)I treatment. Hell J Nucl Med. 2018 Jan-Apr;21(1):83-84. doi: 10.1967/s002449910712. Epub 2018 Mar 20. PubMed PMID: 29550852.
16: Pettem CM, Briens JM, Janz DM, Weber LP. Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine. Aquat Toxicol. 2018 May;198:175-189. doi: 10.1016/j.aquatox.2018.02.022. Epub 2018 Mar 8. PubMed PMID: 29550715.
17: Sele V, Ørnsrud R, Sloth JJ, Berntssen MHG, Amlund H. Selenium and selenium species in feeds and muscle tissue of Atlantic salmon. J Trace Elem Med Biol. 2018 May;47:124-133. doi: 10.1016/j.jtemb.2018.02.005. Epub 2018 Feb 6. PubMed PMID: 29544799.
18: Zakharia Y, Bhattacharya A, Rustum YM. Selenium targets resistance biomarkers enhancing efficacy while reducing toxicity of anti-cancer drugs: preclinical and clinical development. Oncotarget. 2018 Jan 23;9(12):10765-10783. doi: 10.18632/oncotarget.24297. eCollection 2018 Feb 13. Review. PubMed PMID: 29535842; PubMed Central PMCID: PMC5828194.
19: Shi M, Zhang C, Xia IF, Cheung ST, Wong KS, Wong KH, Au DWT, Hinton DE, Kwok KWH. Maternal dietary exposure to selenium nanoparticle led to malformation in offspring. Ecotoxicol Environ Saf. 2018 Jul 30;156:34-40. doi: 10.1016/j.ecoenv.2018.02.073. Epub 2018 Mar 8. PubMed PMID: 29525683.
20: Lu X, He Z, Lin Z, Zhu Y, Yuan L, Liu Y, Yin X. Effects of Chinese Cooking Methods on the Content and Speciation of Selenium in Selenium Bio-Fortified Cereals and Soybeans. Nutrients. 2018 Mar 7;10(3). pii: E317. doi: 10.3390/nu10030317. PubMed PMID: 29518925; PubMed Central PMCID: PMC5872735.