WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562893
CAS#: 493028-20-9
Description: CBFβ Inhibitor is a cell-permeable inhibitor of CBFbeta,. It acts by binding to core binding factor beta.
Hodoodo Cat#: H562893
Name: CBFβ Inhibitor
CAS#: 493028-20-9
Chemical Formula: C12H14N2OS
Exact Mass: 234.08
Molecular Weight: 234.310
Elemental Analysis: C, 61.51; H, 6.02; N, 11.96; O, 6.83; S, 13.68
Synonym: CBFβ Inhibitor; CBFbeta Inhibitor;
IUPAC/Chemical Name: 5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
InChi Key: QHRCVGXBBIRPTE-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)
SMILES Code: NC1=NC(C2=CC=C(OC)C=C2)=C(CC)S1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 234.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia. Adv Exp Med Biol. 2017;962:229-244. doi: 10.1007/978-981-10-3233-2_15. Review. PubMed PMID: 28299661.
2: Berg T. Small-molecule inhibitors of protein-protein interactions. Curr Opin Drug Discov Devel. 2008 Sep;11(5):666-74. Review. PubMed PMID: 18729018.
3: Imai O, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa S, Chiba S, Mitani K, Hirai H. Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. Leuk Lymphoma. 2002 Mar;43(3):617-21. Review. PubMed PMID: 12002768.
4: Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marín-Padilla M. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 1999 Apr 1;59(7 Suppl):1789s-1793s. Review. PubMed PMID: 10197598.