Ara-fluorocytosine

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591305

CAS#: 4298-10-6

Description: Ara-fluorocytosine is a biochemical.

Chemical Structure

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Ara-fluorocytosine
CAS# 4298-10-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H591305
Name: Ara-fluorocytosine
CAS#: 4298-10-6
Chemical Formula: C9H12FN3O5
Exact Mass: 261.08
Molecular Weight: 261.210
Elemental Analysis: C, 41.38; H, 4.63; F, 7.27; N, 16.09; O, 30.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ara-fluorocytosine; NSC 529180; NSC-529180; NSC529180

IUPAC/Chemical Name: 1-beta-D-Arabinofuranosyl-5-fluorocytosine

InChi Key: STRZQWQNZQMHQR-MNCSTQPFSA-N

InChi Code: InChI=1S/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6+,8-/m1/s1

SMILES Code: O=C1N([C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O)C=C(F)C(N)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 261.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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4: Mertelsmann R, Drapkin RL, Gee TS, Kempin S, Passe S, Thaler HT, Arlin Z, Dowling M, Dufour P, McKenzie S, To L, Comacho E, Oettgen HF, Burchenal JH, Clarkson B. Treatment of acute nonlymphocytic leukemia in adults: response to 2,2-anhydro-1-B-D-arabinofuranosyl-5-fluorocytosine and thioguanine on the L-12 protocol. Cancer. 1981 Nov 15;48(10):2136-42. PubMed PMID: 6170414.

5: Watanabe KA, Reichman U, Chu CK, Hollenberg DH, Fox JJ. Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides. J Med Chem. 1980 Oct;23(10):1088-94. PubMed PMID: 7420353.

6: Brugarolas A, Buesa JM, Lacave AJ, Gracia Marco M, Valle Pereda M. Phase I and II clinical study of anhydro-ara-5-fluorocytosine (AAFC) and ICRF-159 combination in adenocarcinoma of digestive origin. Cancer Clin Trials. 1978 Winter;1(4):289-95. PubMed PMID: 93030.

7: Kreis W, Woodcock TM, Meyers MB, Carlevarini LA, Krakoff IH. Physiologic disposition of cytosine arabinoside and its derivatives in man. Cancer Treat Rep. 1977 Jul;61(4):723-6. PubMed PMID: 195729.

8: Cook AF. Fluorinated Pyrimidine nucleosides. 1. Synthesis of a nitrogen analogue of the antitumor agent 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine hydrochloride. J Med Chem. 1977 Mar;20(3):344-8. PubMed PMID: 66315.

9: Basler GA, Shapiro WR. Comparison of 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine and cytosine arabinoside in the treatment of murine brain tumor. Cancer Treat Rep. 1976 Jul;60(7):875-9. PubMed PMID: 64295.

10: Schneyer CA, Galbraith WM. Evaluation of sialogogic action of cyclocytidine (NSC-145668) and anhydro-ara-5-fluorocytidine (NSC-166641). Cancer Chemother Rep. 1975 Sep-Oct;59(5):1019. PubMed PMID: 1203892.

11: Burchenal JH. Murine and human leukemias. Bibl Haematol. 1975;(40):665-77. Review. PubMed PMID: 1100047.